{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T15:56:07Z","timestamp":1764258967469,"version":"3.44.0"},"reference-count":5,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2019,1,23]]},"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:p>Paediatric high-grade gliomas, including glioblastoma and anaplastic astrocytoma, make up 8%\u201312% of paediatric central nervous system tumours\n<jats:sup>1<\/jats:sup>\n and have poor prognosis, with 2-year survival less than 30%\n<jats:sup>2<\/jats:sup>\n and overall survival less than 10%. The only known prognostic factors in this population include extent of resection and tumour histological grade. We present the case of a 9-year-old boy with disseminated anaplastic astrocytoma treated with subtotal resection, craniospinal radiation and temozolomide, with 8-year survival despite metastatic disease at presentation and subtotal resection. Next generation cancer gene panel sequencing revealed an usual pattern of 12 amplifications and four mutations not previously described.<\/jats:p>","DOI":"10.1136\/bcr-2018-228153","type":"journal-article","created":{"date-parts":[[2019,2,14]],"date-time":"2019-02-14T05:03:49Z","timestamp":1550120629000},"page":"e228153","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Atypical anaplastic astrocytoma with unique molecular features and diffuse leptomeningeal spread in a child with long-term survival"],"prefix":"10.1136","volume":"12","author":[{"given":"Yasmin","family":"Aghajan","sequence":"first","affiliation":[{"name":"School of Medicine, UC San Diego, La Jolla, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denise M","family":"Malicki","sequence":"additional","affiliation":[{"name":"Pathology, Rady Children\u2019s Hospital University of California San Diego, San Diego, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael L","family":"Levy","sequence":"additional","affiliation":[{"name":"Neurosurgery, University of California San Diego, San Diego, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John Ross","family":"Crawford","sequence":"additional","affiliation":[{"name":"Neurosciences and Pediatrics, University of California San Diego, San Diego, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,2,13]]},"reference":[{"key":"2025082708513980000_12.2.e228153.1","doi-asserted-by":"publisher","DOI":"10.2217\/cns.14.43"},{"key":"2025082708513980000_12.2.e228153.2","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s11910-012-0250-2","article-title":"Temozolomide for pediatric high-grade gliomas","volume":"12","author":"Packer","year":"2012","journal-title":"Curr Neurol Neurosci Rep"},{"key":"2025082708513980000_12.2.e228153.3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043330"},{"key":"2025082708513980000_12.2.e228153.4","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1007\/s00381-012-1786-9","article-title":"Prognosis of pediatric high-grade gliomas with temozolomide treatment: a retrospective, multicenter study","volume":"28","author":"Jung","year":"2012","journal-title":"Childs Nerv Syst"},{"key":"2025082708513980000_12.2.e228153.5","doi-asserted-by":"crossref","first-page":"210","DOI":"10.5414\/NP300484","article-title":"A common 8q (MYC) amplification detected in a multifocal anaplastic astrocytoma by SNP array karyotyping","volume":"31","author":"Felicella","year":"2012","journal-title":"Clin Neuropathol"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2018-228153","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T15:51:56Z","timestamp":1756309916000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2018-228153"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":5,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2019,2,13]]},"published-print":{"date-parts":[[2019,2]]}},"alternative-id":["10.1136\/bcr-2018-228153"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2018-228153","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2019,2]]}}}