{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T06:10:06Z","timestamp":1756275006699,"version":"3.44.0"},"reference-count":13,"publisher":"BMJ","issue":"5","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2019,4,10]]},"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:p>Nodular primary localised cutaneous amyloidosis (NPLCA) is the rarest form of cutaneous amyloidosis, with a predilection for facial and acral skin. We present a 63-year-old Caucasian with a 10-year history of an asymptomatic plaque on his left cheek, starting 2 years after being scratched by a cat in the same area. A biopsy showed nodules of eosinophilic material in the deep dermis and subcutaneous fat, with plasma cells in the dermis. Congo red staining displayed apple-green birefringence within the eosinophilic material. Immunohistochemistry for serum amyloid P was positive within the eosinophilic material and immunohistochemistry showed lambda light chain restriction within the plasma cells, consistent with NPLCA. The causal relationship of the cat scratch to NPLCA in our patient remains unclear. While trauma-induced amyloidosis has been recognised in papular and macular amyloid, few case reports indicate an association with nodular amyloidosis.<\/jats:p>","DOI":"10.1136\/bcr-2018-228163","type":"journal-article","created":{"date-parts":[[2019,5,7]],"date-time":"2019-05-07T12:23:31Z","timestamp":1557231811000},"page":"e228163","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Curious facial plaque diagnosed as nodular primary localised cutaneous amyloidosis"],"prefix":"10.1136","volume":"12","author":[{"given":"Dawn","family":"Caruana","sequence":"first","affiliation":[{"name":"Department of Dermatology, Queen Elizabeth University Hospital, Glasgow, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1336-5610","authenticated-orcid":false,"given":"Sarah","family":"McCusker","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Queen Elizabeth University Hospital, Glasgow, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Harper","sequence":"additional","affiliation":[{"name":"Department of Pathology, Queen Elizabeth University Hospital, Glasgow, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Bilsland","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Queen Elizabeth University Hospital, Glasgow, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,5,6]]},"reference":[{"key":"2025082622501345000_12.5.e228163.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0047-6374(02)00098-2"},{"key":"2025082622501345000_12.5.e228163.2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-03-413682"},{"key":"2025082622501345000_12.5.e228163.3","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2001.04291.x"},{"key":"2025082622501345000_12.5.e228163.4","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1002\/art.23617","article-title":"Sj\u00f6gren\u2019s syndrome and localized nodular cutaneous amyloidosis: coincidence or a distinct clinical entity?","volume":"58","author":"Meijer","year":"2008","journal-title":"Arthritis Rheum"},{"key":"2025082622501345000_12.5.e228163.5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2007.02541.x"},{"key":"2025082622501345000_12.5.e228163.6","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1111\/j.1365-4632.2009.03799.x","article-title":"Primary localized cutaneous amyloidosis: a sign of immune dysregulation?","volume":"48","author":"Dahdah","year":"2009","journal-title":"Int J Dermatol"},{"key":"2025082622501345000_12.5.e228163.7","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1111\/ced.12305","article-title":"Nodular localized primary cutaneous amyloidosis: a bullous variant","volume":"39","author":"LaChance","year":"2014","journal-title":"Clin Exp Dermatol"},{"key":"2025082622501345000_12.5.e228163.8","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1970.04000070010002"},{"key":"2025082622501345000_12.5.e228163.9","doi-asserted-by":"crossref","first-page":"515","DOI":"10.5021\/ad.2011.23.4.515","article-title":"Primary localized cutaneous nodular amyloidosis following local trauma","volume":"23","author":"Lee","year":"2011","journal-title":"Ann Dermatol"},{"key":"2025082622501345000_12.5.e228163.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.12.014"},{"key":"2025082622501345000_12.5.e228163.11","first-page":"89","article-title":"Primary localized cutaneous nodular amyloidosis of the feet: a case report and review of the literature","volume":"93","author":"Ritchie","year":"2014","journal-title":"Cutis"},{"key":"2025082622501345000_12.5.e228163.12","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.22.4.410"},{"key":"2025082622501345000_12.5.e228163.13","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2007070757"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2018-228163","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T05:50:21Z","timestamp":1756273821000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2018-228163"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":13,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2019,5,6]]},"published-print":{"date-parts":[[2019,5]]}},"alternative-id":["10.1136\/bcr-2018-228163"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2018-228163","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2019,5]]}}}