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Multiple NOFs associated with NF1 are rare but can coalesce resulting in large lesions with an increased risk of pathological fracture. In cases which permit, non-operative treatment with cast immobilisation can yield satisfactory results.<\/jats:p>","DOI":"10.1136\/bcr-2018-228170","type":"journal-article","created":{"date-parts":[[2019,7,22]],"date-time":"2019-07-22T05:25:17Z","timestamp":1563773117000},"page":"e228170","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Pathological fracture of non-ossifying fibroma associated with neurofibromatosis type 1"],"prefix":"10.1136","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8279-3697","authenticated-orcid":false,"given":"James Ritchie","family":"Gill","sequence":"first","affiliation":[{"name":"Trauma and Orthopaedics, Peterborough and Stamford Hospitals NHS Foundation Trust, Peterborough, Cambridgeshire, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamer Magid","family":"EL Nakhal","sequence":"additional","affiliation":[{"name":"Trauma and Orthopaedics, Peterborough and Stamford Hospitals NHS Foundation Trust, Peterborough, Cambridgeshire, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo-Mi","family":"Park","sequence":"additional","affiliation":[{"name":"Clinical Genetics, Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariusz","family":"Chomicki","sequence":"additional","affiliation":[{"name":"Trauma and Orthopaedics, Peterborough and Stamford Hospitals NHS Foundation Trust, Peterborough, Cambridgeshire, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2019,7,21]]},"reference":[{"key":"2025082622424206000_12.7.e228170.1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.141.1.71"},{"key":"2025082622424206000_12.7.e228170.2","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/BF00197259","article-title":"Preferential mutation of the neurofibromatosis type 1 gene in paternally derived chromosomes","volume":"88","author":"Stephens","year":"1992","journal-title":"Hum Genet"},{"key":"2025082622424206000_12.7.e228170.3","doi-asserted-by":"crossref","first-page":"217","DOI":"10.5435\/00124635-199907000-00002","article-title":"Neurofibromatosis in children: the role of the orthopaedist","volume":"7","author":"Crawford","year":"1999","journal-title":"J Am Acad Orthop Surg"},{"key":"2025082622424206000_12.7.e228170.4","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0065-3101(22)00436-4","article-title":"On fibrous defects in cortical walls of growing tubular bones: their radiologic appearance, structure, prevalence, natural course, and diagnostic significance","volume":"7","author":"Caffey","year":"1955","journal-title":"Adv Pediatr"},{"key":"2025082622424206000_12.7.e228170.5","first-page":"179","article-title":"[Non-ossifying fibroma in children: a surgical condition?]","volume":"21","author":"Mallet","year":"1980","journal-title":"Chir Pediatr"},{"key":"2025082622424206000_12.7.e228170.6","first-page":"1","article-title":"Non-ossifying fibroma, fibrous cortical defect and Jaffe-Campanacci syndrome: a biologic and clinical review","volume":"93","author":"Mankin","year":"2009","journal-title":"Chir Organi Mov"},{"key":"2025082622424206000_12.7.e228170.7","doi-asserted-by":"crossref","first-page":"89","DOI":"10.5435\/00124635-200403000-00004","article-title":"Metaphyseal fibrous defects","volume":"12","author":"Betsy","year":"2004","journal-title":"J Am Acad Orthop Surg"},{"key":"2025082622424206000_12.7.e228170.8","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1097\/00001888-195901000-00023","article-title":"Tumors and Tumorous Conditions of the Bones and Joints","volume":"34","author":"Jaffe","year":"1959","journal-title":"Academic Medicine"},{"key":"2025082622424206000_12.7.e228170.9","doi-asserted-by":"crossref","unstructured":"Mirra JM , Gold RH , Rand F . 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