{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:02:55Z","timestamp":1790614975307,"version":"4.1.0"},"reference-count":26,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:p>A 44-year-old Caucasian man with a history of deceased donor renal transplant for end-stage renal disease from Alport\u2019s syndrome (AS), presented with a spontaneous subarachnoid haemorrhage and hydrocephalus. Following an external ventricular drain for the hydrocephalus, a CT angiography revealed a dissection of the left vertebral artery extending into vertebro-basilar junction necessitating a bypass between left occipital artery to left posterior inferior cerebellar artery. He had a posterior fossa Craniectomy, C1 laminectomy and coiling off, of the left vertebral artery. Postprocedure course was prolonged but uneventful with complete recovery and normal renal function 18 months postpresentation. AS, a disease caused by abnormalities in the synthesis of type IV collagen, can cause aneurysms with severe and permanent neurological sequalae. We present a case of AS with intracranial arterial dissection with potential life-threatening consequences and discuss the genetic and molecular basis of AS along with review of the relevant literature.<\/jats:p>","DOI":"10.1136\/bcr-2018-228175","type":"journal-article","created":{"date-parts":[[2019,1,31]],"date-time":"2019-01-31T04:09:19Z","timestamp":1548907759000},"page":"e228175","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Alport\u2019s syndrome and intracranial aneurysm: mere coincidence or undiscovered causal relationship"],"prefix":"10.1136","volume":"12","author":[{"given":"Subhasish","family":"Bose","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samata","family":"Pathireddy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishna M","family":"Baradhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narothama Reddy","family":"Aeddula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2019,1,29]]},"reference":[{"key":"2019013002251776000_12.1.e228175.1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.3454.504"},{"key":"2019013002251776000_12.1.e228175.2"},{"key":"2019013002251776000_12.1.e228175.3","first-page":"26","article-title":"Report on management of renal failure in children in Europe, XXIII, 1992","volume":"9","author":"Loirat","year":"1994","journal-title":"Nephrol Dial Transplant"},{"key":"2019013002251776000_12.1.e228175.4","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-199909000-00005"},{"key":"2019013002251776000_12.1.e228175.5","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119431"},{"key":"2019013002251776000_12.1.e228175.6","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-3019(00)00253-6"},{"key":"2019013002251776000_12.1.e228175.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2007.06.004"},{"key":"2019013002251776000_12.1.e228175.8","doi-asserted-by":"publisher","DOI":"10.5301\/jva.5000167"},{"key":"2019013002251776000_12.1.e228175.9","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1080\/01616412.1990.11739952","article-title":"Pathogenesis and histopathology of saccular aneurysms: review of the literature","volume":"12","author":"Yong-Zhong","year":"1990","journal-title":"Neurol Res"},{"key":"2019013002251776000_12.1.e228175.10","doi-asserted-by":"publisher","DOI":"10.3109\/02688699109002879"},{"key":"2019013002251776000_12.1.e228175.11","first-page":"287","article-title":"Intracranial saccular aneurysms in the first three decades","volume":"9","author":"Yoshimoto","year":"1978","journal-title":"Surg Neurol"},{"key":"2019013002251776000_12.1.e228175.12","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-006-0142-3"},{"key":"2019013002251776000_12.1.e228175.13","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1983.58.6.0832"},{"key":"2019013002251776000_12.1.e228175.14","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1971.35.5.0571"},{"key":"2019013002251776000_12.1.e228175.15","doi-asserted-by":"publisher","DOI":"10.3109\/02688698909001033"},{"key":"2019013002251776000_12.1.e228175.16","doi-asserted-by":"crossref","first-page":"551","DOI":"10.3109\/02688699109002878","article-title":"Type III collagen mutations cause fragile cerebral arteries","volume":"5","author":"Pope","year":"1991","journal-title":"Br J Neurosurg"},{"key":"2019013002251776000_12.1.e228175.17","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1987.67.5.0690"},{"key":"2019013002251776000_12.1.e228175.18","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410380620"},{"key":"2019013002251776000_12.1.e228175.19","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.25.4.889"},{"key":"2019013002251776000_12.1.e228175.20","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1986.00520010026015"},{"key":"2019013002251776000_12.1.e228175.21","first-page":"484","article-title":"Failure of elastin or collagen as possible critical connective tissue alterations underlying aneurysmal dilatation","volume":"2","author":"Dobrin","year":"1994","journal-title":"Cardiovasc Surg"},{"key":"2019013002251776000_12.1.e228175.22","first-page":"736","article-title":"[Fibromuscular dysplasia with moyamoya phenomenon in a patient with Alport\u2019s syndrome. 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