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She was treated with cyclophosphamide, doxorubicin, vincristine, etoposide and prednisolone chemotherapy that was changed to salvage ifosfamide carboplatin etoposide (ICE) chemotherapy due to poor response with first-line chemotherapy and disease progression. Unfortunately, her disease progressed further and she opted for palliative management.<\/jats:p>","DOI":"10.1136\/bcr-2018-228186","type":"journal-article","created":{"date-parts":[[2019,3,22]],"date-time":"2019-03-22T06:45:25Z","timestamp":1553237125000},"page":"e228186","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Hepatosplenic T cell lymphoma presenting as multiorgan failure"],"prefix":"10.1136","volume":"12","author":[{"given":"Puraskar","family":"Pateria","sequence":"first","affiliation":[{"name":"Gastroenterology and Hepatology, Fiona Stanley Hospital, Murdoch, Western Australia, Australia"},{"name":"Gastroenterology and Hepatology, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annalise","family":"Martin","sequence":"additional","affiliation":[{"name":"Haematology, Fiona Stanley Hospital, Murdoch, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tze Sheng","family":"Khor","sequence":"additional","affiliation":[{"name":"Pathwest Laboratory Medicine, PathWest Laboratory Medicine Western Australia, Nedlands, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanoo","family":"Jayasekeran","sequence":"additional","affiliation":[{"name":"Fiona Stanley Hospital, Murdoch, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,3,21]]},"reference":[{"key":"2025082723060616000_12.3.e228186.1","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1111\/imj.12363","article-title":"Hepatosplenic T-cell lymphoma, immunosuppressive agents and biologicals: what are the risks?","volume":"44","author":"Subramaniam","year":"2014","journal-title":"Intern Med J"},{"key":"2025082723060616000_12.3.e228186.2","doi-asserted-by":"crossref","first-page":"464","DOI":"10.5694\/j.1326-5377.2008.tb02124.x","article-title":"Hepatosplenic T-cell lymphoma following infliximab therapy for Crohn\u2019s disease","volume":"189","author":"Drini","year":"2008","journal-title":"Med J Aust"},{"key":"2025082723060616000_12.3.e228186.3","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdn751"},{"key":"2025082723060616000_12.3.e228186.4","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1097\/PAS.0000000000000743","article-title":"Distinguishing between hepatosplenic t-cell lymphoma and \u03b3\u03b4 t-cell large granular lymphocytic leukemia: a clinicopathologic, immunophenotypic, and molecular analysis","volume":"41","author":"Yabe","year":"2017","journal-title":"Am J Surg Pathol"},{"key":"2025082723060616000_12.3.e228186.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2010.09.016"},{"key":"2025082723060616000_12.3.e228186.6","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-05-1675"},{"key":"2025082723060616000_12.3.e228186.7","doi-asserted-by":"publisher","DOI":"10.1309\/LRKX8CE7GVPCR1FT"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2018-228186","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T06:06:13Z","timestamp":1756361173000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2018-228186"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":7,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2019,3,21]]},"published-print":{"date-parts":[[2019,3]]}},"alternative-id":["10.1136\/bcr-2018-228186"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2018-228186","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2019,3]]}}}