{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T18:10:01Z","timestamp":1756318201630,"version":"3.44.0"},"reference-count":9,"publisher":"BMJ","issue":"3","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2019,2,12]]},"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:p>We present a case of constrictive pericarditis with concomitant blood and bone marrow appearances of chronic myelomonocytic leukaemia (CMML). Despite surgical treatment with pericardiectomy, the patient deteriorated into multiorgan failure. Pericardial histology disclosed a typical inflammatory picture with no evidence of monocytic or malignant infiltrate. Following intensive collaboration between cardiologists, haematologists and rheumatologists via daily email exchanges, a diagnosis was reached of autoinflammatory constrictive pericarditis with a non-infiltrative coexisting CMML. The key to achieving a rapid and sustained response was a trial of high-dose steroids followed by intravenous immunoglobulins. This achieved restoration of cardiac function, resolution of symptoms and near normalisation of inflammatory markers. A diagnosis of concurrent CMML was confirmed at 3 months. The patient remains well, taking colchicine and steroids.<\/jats:p>","DOI":"10.1136\/bcr-2018-228204","type":"journal-article","created":{"date-parts":[[2019,3,8]],"date-time":"2019-03-08T05:10:54Z","timestamp":1552021854000},"page":"e228204","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Autoinflammatory constrictive pericarditis and chronic myelomonocytic leukaemia: when one speciality is not enough"],"prefix":"10.1136","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4644-8391","authenticated-orcid":false,"given":"Frances","family":"Varian","sequence":"first","affiliation":[{"name":"Department of Cardiology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harpreet","family":"Kaur","sequence":"additional","affiliation":[{"name":"Department of Haematology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stuart","family":"Carter","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julian","family":"Gunn","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Unit, Sheffield Teaching Hospitals and University of Sheffield, Sheffield, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,3,7]]},"reference":[{"key":"2025082710544367000_12.3.e228204.1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv318"},{"key":"2025082710544367000_12.3.e228204.2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-03-643544"},{"key":"2025082710544367000_12.3.e228204.3","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1989.00390010165024"},{"key":"2025082710544367000_12.3.e228204.4","first-page":"17","article-title":"Recurrent unilateral pleural effusion from constrictive pericarditis of unknown aetiology requiring pericardiectomy","volume":"15","author":"Aishah","year":"2015","journal-title":"The Medicine Forum"},{"key":"2025082710544367000_12.3.e228204.5","first-page":"2451","article-title":"Constrictive pericarditis presenting as bilateral pleural effusion: a report of two cases","volume":"10","author":"Gangwani","year":"2018","journal-title":"Cureus"},{"key":"2025082710544367000_12.3.e228204.6","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1002\/ccr3.55","article-title":"Chronic myelomonocytic leukemia presenting with polyserositis due to an immune-mediated monocyte activation","volume":"2","author":"Imataki","year":"2014","journal-title":"Clin Case Rep"},{"key":"2025082710544367000_12.3.e228204.7","first-page":"1","volume-title":"New Insights into Pericarditis: mechanisms of injury","volume":"19","author":"Xu","year":"2017"},{"key":"2025082710544367000_12.3.e228204.8","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-08-452938"},{"key":"2025082710544367000_12.3.e228204.9","first-page":"16","article-title":"Acute pericarditis","volume":"12","author":"Valladares","year":"2014","journal-title":"E journal of Cardiology Practice"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2018-228204","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T17:54:50Z","timestamp":1756317290000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2018-228204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":9,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2019,3,7]]},"published-print":{"date-parts":[[2019,3]]}},"alternative-id":["10.1136\/bcr-2018-228204"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2018-228204","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2019,3]]}}}