{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:28:36Z","timestamp":1762507716022,"version":"3.44.0"},"reference-count":15,"publisher":"BMJ","issue":"3","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2019,2,3]]},"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:p>Epithelial ovarian cancers typically spread by intraperitoneal exfoliation and retroperitoneal lymph nodal involvement along the ovarian vascular supply. Pericardial involvement in ovarian malignancies is very rare with only few cases reported in the literature. Malignancy is the most common cause for pericardial effusion in the western world. In this case report, we present a 58-year-old woman treated for high-grade serous carcinoma of the ovary in 2010, relapsed with pericardial effusion and cardiac tamponade in 2017. Imaging studies revealed gross pericardial effusion. Two-dimensional echocardiogram showed massive pericardial effusion, with cardiac tamponade, New York Heart Association\u2014IV. Pericardiocentesis and pigtail drain was placed under echo guidance. Immunocytochemistry has confirmed the tumour cells to be of the ovarian origin. The patient underwent surgical pericardial window via thoracotomy, followed by paclitaxel and carboplatin-based chemotherapy and olaparib maintenance.<\/jats:p>","DOI":"10.1136\/bcr-2018-228268","type":"journal-article","created":{"date-parts":[[2019,3,23]],"date-time":"2019-03-23T04:07:32Z","timestamp":1553314052000},"page":"e228268","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Platinum sensitive carcinoma of ovary relapsed as pericardial effusion with cardiac tamponade"],"prefix":"10.1136","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8921-0957","authenticated-orcid":false,"given":"Chinna Babu","family":"Dracham","sequence":"first","affiliation":[{"name":"Radiotherapy and Oncology, Post Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shipra","family":"Gupta","sequence":"additional","affiliation":[{"name":"Radiotherapy and Oncology, Post Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2159-8227","authenticated-orcid":false,"given":"Chandan Krushna","family":"Das","sequence":"additional","affiliation":[{"name":"Radiotherapy and Oncology, Post Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7849-5280","authenticated-orcid":false,"given":"Arun","family":"Elangovan","sequence":"additional","affiliation":[{"name":"Radiotherapy and Oncology, Post Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,3,22]]},"reference":[{"key":"2025082709483910000_12.3.e228268.1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.00.745"},{"key":"2025082709483910000_12.3.e228268.2","first-page":"673","article-title":"Neoplastic pericardial disease","volume":"8","author":"Hancock","year":"1990","journal-title":"Cardiol Clin"},{"key":"2025082709483910000_12.3.e228268.3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra022643"},{"key":"2025082709483910000_12.3.e228268.4","doi-asserted-by":"publisher","DOI":"10.1002\/clc.20936"},{"key":"2025082709483910000_12.3.e228268.5","first-page":"337","article-title":"Malignant pericardial tamponade secondary to papillary serous adenocarcinoma of the ovary","volume":"9","author":"Blich","year":"2007","journal-title":"Isr Med Assoc J"},{"key":"2025082709483910000_12.3.e228268.6","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.jemermed.2015.04.024","article-title":"Malignant Pericardial Effusion in Ovarian Malignancy: A Treatable Oncologic Emergency","volume":"49","author":"Perri","year":"2015","journal-title":"J Emerg Med"},{"key":"2025082709483910000_12.3.e228268.7","first-page":"627","article-title":"Cardiac tamponade","volume":"8","author":"Reddy","year":"1990","journal-title":"Cardiol Clin"},{"key":"2025082709483910000_12.3.e228268.8","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1007\/s00404-009-0976-5","article-title":"Malignant pericardial effusion with cardiac tamponade in ovarian adenocarcinoma","volume":"280","author":"Petersen","year":"2009","journal-title":"Arch Gynecol Obstet"},{"key":"2025082709483910000_12.3.e228268.9","doi-asserted-by":"publisher","DOI":"10.1378\/chest.126.5.1412"},{"key":"2025082709483910000_12.3.e228268.10","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(97)00992-2"},{"key":"2025082709483910000_12.3.e228268.11","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.gynor.2014.06.001","article-title":"The natural history of pericardial tamponade secondary to recurrent ovarian carcinoma - A case report and review of the literature","volume":"10","author":"Feferkorn","year":"2014","journal-title":"Gynecol Oncol Rep"},{"key":"2025082709483910000_12.3.e228268.12","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.40.6.700"},{"key":"2025082709483910000_12.3.e228268.13","doi-asserted-by":"crossref","first-page":"443","DOI":"10.3109\/00016348509155164","article-title":"Pericardial effusion in advanced ovarian carcinoma. 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