{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T11:33:29Z","timestamp":1774438409140,"version":"3.50.1"},"reference-count":11,"publisher":"BMJ","issue":"4","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2019,4,3]]},"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:p>Gallbladder diseases are uncommon in children. Acalculous acute cholecystitis, although rare, is the most frequent form of acute cholecystitis in childhood. In acalculous acute cholecystitis, clinical presentation and laboratory findings are unspecific, making the diagnosis challenging. Abdominal ultrasonography is the first-line exam. Most cases of paediatric acalculous acute cholecystitis have been described in critically ill patients, but can occur in previously healthy children, without underlying diseases or severe conditions. The authors present a clinical report of a child with acalculous acute cholecystitis and enteroviral infection. Diagnosis, treatment, clinical course and prognosis are described. Pathophysiology, aetiology, diagnosis and treatment of acalculous acute cholecystitis are also discussed.<\/jats:p>","DOI":"10.1136\/bcr-2018-228306","type":"journal-article","created":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T14:24:16Z","timestamp":1554992656000},"page":"e228306","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Acalculous acute cholecystitis during the course of an enteroviral infection"],"prefix":"10.1136","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8443-0689","authenticated-orcid":false,"given":"Ana Sofia","family":"Sim\u00f5es","sequence":"first","affiliation":[{"name":"Hospital Pediatrico de Coimbra, Coimbra, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreia","family":"Marinhas","sequence":"additional","affiliation":[{"name":"Hospital Pediatrico de Coimbra, Coimbra, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo","family":"Coelho","sequence":"additional","affiliation":[{"name":"Hospital Pediatrico de Coimbra, Coimbra, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Hospital Pediatrico de Coimbra, Coimbra, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,4,11]]},"reference":[{"key":"2025082707154016000_12.4.e228306.1","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.3346\/jkms.2016.31.10.1617","article-title":"Age, predisposing diseases, and ultrasonographic findings in determining clinical outcome of acute acalculous inflammatory gallbladder diseases in children","volume":"31","author":"Yi","year":"2016","journal-title":"J Korean Med Sci"},{"key":"2025082707154016000_12.4.e228306.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2010.02.012"},{"key":"2025082707154016000_12.4.e228306.3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2015\/459608","article-title":"Acalculous acute cholecystitis in previously healthy children: general overview and analysis of pediatric infectious cases","volume":"2015","author":"Poddighe","year":"2015","journal-title":"Int J Hepatol"},{"key":"2025082707154016000_12.4.e228306.4","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.pedneo.2016.12.005","article-title":"Risk factors for poor outcomes of children with acute acalculous cholecystitis","volume":"58","author":"Lu","year":"2017","journal-title":"Pediatr Neonatol"},{"key":"2025082707154016000_12.4.e228306.5","doi-asserted-by":"crossref","first-page":"e25","DOI":"10.1016\/j.jpedsurg.2007.10.073","article-title":"Acute acalculous cholecystitis of viral etiology\u2014a rare condition in children?","volume":"43","author":"Gora-Gebka","year":"2008","journal-title":"J Pediatr Surg"},{"key":"2025082707154016000_12.4.e228306.6","first-page":"57","article-title":"Acute acalculous cholecystitis associated with severe EBV hepatitis in an immunocompetent child","volume":"17","author":"Poddighe","year":"2014","journal-title":"BMJ Case Rep"},{"key":"2025082707154016000_12.4.e228306.7","doi-asserted-by":"crossref","first-page":"4870","DOI":"10.3748\/wjg.v24.i43.4870","article-title":"Acute acalculous cholecystitis in children","volume":"24","author":"Poddighe","year":"2018","journal-title":"World J Gastroenterol"},{"key":"2025082707154016000_12.4.e228306.8","doi-asserted-by":"publisher","DOI":"10.1542\/pir.19-6-183"},{"key":"2025082707154016000_12.4.e228306.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijscr.2014.06.006"},{"key":"2025082707154016000_12.4.e228306.10","doi-asserted-by":"publisher","DOI":"10.1136\/bcr.03.2010.2787"},{"key":"2025082707154016000_12.4.e228306.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2009.08.034"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2018-228306","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T14:15:49Z","timestamp":1756304149000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2018-228306"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":11,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2019,4,11]]},"published-print":{"date-parts":[[2019,4]]}},"alternative-id":["10.1136\/bcr-2018-228306"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2018-228306","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4]]}}}