{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T17:10:01Z","timestamp":1756314601265,"version":"3.44.0"},"reference-count":8,"publisher":"BMJ","issue":"8","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2019,7,30]]},"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:p>A 78-year-old woman visited the emergency department with complaints of progressively worsening abdominal pain for a week. Nausea and vomiting started at the time of the visit. An abdominal contrast-enhanced CT (CECT) revealed a filling defect of portal vein, splenic vein and superior mesenteric vein (SMV) which was diagnosed as portal vein and mesenteric venous thrombosis (MVT). Intravenous administration of unfractionated heparin was initiated. However, her symptoms did not improve, and she underwent surgical thrombectomy on the second day of hospitalisation. On the sixth day, CECT revealed the recurrence of thrombi in the portal vein, SMV and along the central venous catheters. We switched heparin to argatroban on the eighth day. After administering argatroban, CECT revealed that the thrombi had almost disappeared by the 40th day. In this case, argatroban was considered effective for heparin-resistant and surgery-resistant portal vein and MVT.<\/jats:p>","DOI":"10.1136\/bcr-2018-228427","type":"journal-article","created":{"date-parts":[[2019,8,16]],"date-time":"2019-08-16T03:45:12Z","timestamp":1565927112000},"page":"e228427","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Successful intravenous administration of argatroban in the management of heparin-resistant and surgery-resistant mesenteric vein thrombosis"],"prefix":"10.1136","volume":"12","author":[{"given":"Yuya","family":"Yokota","sequence":"first","affiliation":[{"name":"Department of General Internal Medicine, Okayama Kyoritsu Hospital, Okayama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7709-8278","authenticated-orcid":false,"given":"Takashi","family":"Yoshioka","sequence":"additional","affiliation":[{"name":"Center for Innovative Research for Communities and Clinical Excellence (CiRC2LE), Fukushima Medical University, Fukushima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayumi","family":"Senoh","sequence":"additional","affiliation":[{"name":"Department of General Internal Medicine, Okayama Kyoritsu Hospital, Okayama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuharu","family":"Sunami","sequence":"additional","affiliation":[{"name":"Department of General Internal Medicine, Okayama Kyoritsu Hospital, Okayama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,8,15]]},"reference":[{"key":"2025082709530901000_12.8.e228427.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2013.01.012"},{"key":"2025082709530901000_12.8.e228427.2","doi-asserted-by":"publisher","DOI":"10.1177\/1358863X10379673"},{"key":"2025082709530901000_12.8.e228427.3","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.5028"},{"key":"2025082709530901000_12.8.e228427.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2004.10.005"},{"key":"2025082709530901000_12.8.e228427.5","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(00)70183-1"},{"key":"2025082709530901000_12.8.e228427.6","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1055\/s-2007-996129","article-title":"a direct thrombin inhibitor, and its clinical application","volume":"23","author":"Matsuo","year":"1997","journal-title":"Semin Thromb Hemost"},{"key":"2025082709530901000_12.8.e228427.7","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1055\/s-0037-1612952","article-title":"Enhancement of endogenous plasminogen activator-induced thrombolysis by argatroban and APC and its control by TAFI, measured in an arterial thrombolysis model in vivo using rat mesenteric arterioles","volume":"87","author":"Hashimoto","year":"2002","journal-title":"Thromb Haemost"},{"key":"2025082709530901000_12.8.e228427.8","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.3892\/etm.2017.4103","article-title":"Early initiation of argatroban therapy in the management of acute superior mesenteric venous thrombosis","volume":"13","author":"Zeng","year":"2017","journal-title":"Exp Ther Med"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2018-228427","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T16:53:18Z","timestamp":1756313598000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2018-228427"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":8,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2019,8,15]]},"published-print":{"date-parts":[[2019,8]]}},"alternative-id":["10.1136\/bcr-2018-228427"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2018-228427","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2019,8]]}}}