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Treatment depends on the severity of the disease, ranging from pharmacological treatment to surgical approach. However, EG is also reported to possibly undergo spontaneous resolution. In this case report, we describe a rare case of EG with particularly aggressive behaviour in a young patient. Initially, local pharmacological treatment with intralesional administration of corticosteroids lead to worsening of the symptoms, increase in lesion\u2019s dimensions, and disruption of the cortical bone. A more invasive therapeutic approach involving radical surgery was then performed, with consequent resolution of the disease.<\/jats:p>","DOI":"10.1136\/bcr-2018-228455","type":"journal-article","created":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T09:55:38Z","timestamp":1557136538000},"page":"e228455","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Cone Beam CT study of a case of eosinophilic granuloma of the mandible in a young patient"],"prefix":"10.1136","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4902-7813","authenticated-orcid":false,"given":"Rossana","family":"Izzetti","sequence":"first","affiliation":[{"name":"Department of Translational Research and of New Surgical and Medical Technologies, University of Pisa, Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"De Marco","sequence":"additional","affiliation":[{"name":"Paediatric Haematology and Oncology, Univerisity Hospital of Pisa, Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Caramella","sequence":"additional","affiliation":[{"name":"Diagnostic and Interventional Radiology, University of Pisa, Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2019,5,5]]},"reference":[{"key":"2025082701092186000_12.5.e228455.1","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1177\/0194599815598969","article-title":"Isolated langerhans cell histiocytosis bone lesion in pediatric patients","volume":"153","author":"Bezdjian","year":"2015","journal-title":"Otolaryngology\u2013Head and Neck Surgery"},{"key":"2025082701092186000_12.5.e228455.2","unstructured":"Young BD , Egeler RM , Rollins BJ , . et al Langerhans cell histiocytosis. 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