{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T03:39:05Z","timestamp":1760240345948,"version":"3.44.0"},"reference-count":47,"publisher":"BMJ","issue":"3","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2019,3,3]]},"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:p>Glycogenic hepatopathy (GH) is a rare complication of poorly controlled type 1 diabetes mellitus (T1DM). We present a 19-year-old woman with T1DM and autoimmune thyroiditis who admitted to our department because of abrupt onset intermittent abdominal pain in the right upper quadrant accompanied by laboratory evidence of acute anicteric hepatitis. Physical examination revealed significant hepatomegaly but the common imagining studies were negative. Following exclusion of common causes of acute hepatitis and because of the presence of smooth muscle antibodies in a young female patient with already established two autoimmune diseases, a liver biopsy was performed in order to exclude the potential presence of autoimmune hepatitis. However, liver histology showed typical findings of GH. Intense treatment targeting strict glycemic control resulted in normalisation of liver biochemistry. This case underlines that GH should be considered as a rare cause of acute hepatitis in T1DM patients with poor glycemic control.<\/jats:p>","DOI":"10.1136\/bcr-2018-228524","type":"journal-article","created":{"date-parts":[[2019,3,21]],"date-time":"2019-03-21T05:17:56Z","timestamp":1553145476000},"page":"e228524","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Glycogenic hepatopathy as a cause of severe deranged liver enzymes in a young patient with type 1 diabetes mellitus"],"prefix":"10.1136","volume":"12","author":[{"given":"Kalliopi","family":"Azariadis","sequence":"first","affiliation":[{"name":"Department of Medicine and Research Laboratory of Internal Medicine, University Hospital of Larissa, Larissa, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolaos K","family":"Gatselis","sequence":"additional","affiliation":[{"name":"Department of Medicine and Research Laboratory of Internal Medicine, University Hospital of Larissa, Larissa, Greece"},{"name":"Institute of Internal Medicine and Hepatology, Larissa, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George K","family":"Koukoulis","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Thessaly, Medical School, Larissa, Thessaly, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7075-8464","authenticated-orcid":false,"given":"Georgios N","family":"Dalekos","sequence":"additional","affiliation":[{"name":"Department of Medicine and Research Laboratory of Internal Medicine, University Hospital of Larissa, Larissa, Greece"},{"name":"Institute of Internal Medicine and Hepatology, Larissa, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,3,20]]},"reference":[{"key":"2025082622523378000_12.3.e228524.1","first-page":"57","article-title":"[Hepatomegaly, dwarfism, obesity and diabetes in children: Mauriac\u2019s syndrome]","volume":"67","author":"Mauriac","year":"1951","journal-title":"Vida Nueva"},{"key":"2025082622523378000_12.3.e228524.2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200604000-00012"},{"key":"2025082622523378000_12.3.e228524.3","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/S1665-2681(19)31472-3","article-title":"\u00a0Glycogenic hepatopathy associated with type 1 diabetes mellitus as a cause of recurrent liver damage","volume":"11","author":"Messeri","year":"2012","journal-title":"Ann Hepatol"},{"key":"2025082622523378000_12.3.e228524.4","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v6.i2.321"},{"key":"2025082622523378000_12.3.e228524.5","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117727"},{"key":"2025082622523378000_12.3.e228524.6","doi-asserted-by":"publisher","DOI":"10.1210\/rp.56.1.219"},{"key":"2025082622523378000_12.3.e228524.7","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.1.49"},{"key":"2025082622523378000_12.3.e228524.8","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12470"},{"key":"2025082622523378000_12.3.e228524.9","doi-asserted-by":"crossref","first-page":"60","DOI":"10.3748\/wjg.v21.i1.60","article-title":"Autoimmune hepatitis, one disease with many faces: etiopathogenetic, clinico-laboratory and histological characteristics","volume":"21","author":"Gatselis","year":"2015","journal-title":"World J Gastroenterol"},{"key":"2025082622523378000_12.3.e228524.10","doi-asserted-by":"publisher","DOI":"10.1016\/S0953-6205(02)00089-4"},{"key":"2025082622523378000_12.3.e228524.11","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1080\/14737159.2016.1217159","article-title":"Molecular diagnostic testing for primary biliary cholangitis","volume":"16","author":"Gatselis","year":"2016","journal-title":"Expert Rev Mol Diagn"},{"key":"2025082622523378000_12.3.e228524.12","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22322"},{"key":"2025082622523378000_12.3.e228524.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.06.030"},{"key":"2025082622523378000_12.3.e228524.14","first-page":"1","article-title":"Hellenic association for the study of the liver clinical practice guidelines: autoimmune hepatitis","volume":"32","author":"Dalekos","year":"2019","journal-title":"Ann Gastroenterol"},{"key":"2025082622523378000_12.3.e228524.15","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.hbpd.2018.02.006","article-title":"Glycogenic hepatopathy","volume":"17","author":"Khoury","year":"2018","journal-title":"Hepatobiliary Pancreat Dis Int"},{"key":"2025082622523378000_12.3.e228524.16","doi-asserted-by":"crossref","first-page":"6037530","DOI":"10.1155\/2018\/6037530","article-title":"Young man with hepatomegaly: a case of glycogenic hepatopathy","volume":"2018","author":"Abboud","year":"2018","journal-title":"Case Reports Hepatol"},{"key":"2025082622523378000_12.3.e228524.17","first-page":"e255","article-title":"Glycogenic hepatopathy: a complication of uncontrolled diabetes","volume":"3","author":"Satyarengga","year":"2017","journal-title":"AACE Clin Case Rep"},{"key":"2025082622523378000_12.3.e228524.18","doi-asserted-by":"crossref","first-page":"e31","DOI":"10.14309\/crj.2018.31","article-title":"An unusual presentation of glycogenic hepatopathy with bridging fibrosis","volume":"5","author":"Sherigar","year":"2018","journal-title":"ACG Case Rep J"},{"key":"2025082622523378000_12.3.e228524.19","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2013-304426"},{"key":"2025082622523378000_12.3.e228524.20","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.cgh.2016.11.038","article-title":"Clinical, biochemical, and histopathology features of patients with glycogenic hepatopathy","volume":"15","author":"Mukewar","year":"2017","journal-title":"Clin Gastroenterol Hepatol"},{"key":"2025082622523378000_12.3.e228524.21","doi-asserted-by":"crossref","first-page":"E201","DOI":"10.1111\/hepr.12713","article-title":"Four cases of type 1 diabetes mellitus showing sharp serum transaminase increases and hepatomegaly due to glycogenic hepatopathy","volume":"47","author":"Ikarashi","year":"2017","journal-title":"Hepatol Res"},{"key":"2025082622523378000_12.3.e228524.22","first-page":"184","article-title":"Hepatic glycogen storage during uncontrolled diabetes mellitus. A case report","volume":"47","author":"Berman","year":"1973","journal-title":"S Afr Med J"},{"key":"2025082622523378000_12.3.e228524.23","doi-asserted-by":"crossref","unstructured":"Chen Z-y , Liu Y-p , Zhou D-j . Hepatobiliary and Pancreatic: Glycogenic hepatopathy in a patient with poorly controlled diabetes mellitus mimics a hepatic neoplasm. J Gastroenterol Hepatol 2018.doi:10.1111\/jgh.14505","DOI":"10.1111\/jgh.14505"},{"key":"2025082622523378000_12.3.e228524.24","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.2169\/internalmedicine.9490-17","article-title":"Glycogenic hepatopathy in type 1 diabetes mellitus","volume":"57","author":"Asada","year":"2018","journal-title":"Intern Med"},{"key":"2025082622523378000_12.3.e228524.25","first-page":"6072909","article-title":"A rare case of persistent lactic acidosis in the icu: glycogenic hepatopathy and mauriac syndrome","volume":"2016","author":"Deemer","year":"2016","journal-title":"Case Rep Crit Care"},{"key":"2025082622523378000_12.3.e228524.26","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1111\/cob.12154","article-title":"Unusual glycogenic hepatopathy causing abnormal liver enzymes in a morbidly obese adolescent with well-controlled type 2 diabetes: resolved after A1c was normalized by metformin","volume":"6","author":"Umpaichitra","year":"2016","journal-title":"Clin Obes"},{"key":"2025082622523378000_12.3.e228524.27","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1754.2000.00547.x"},{"key":"2025082622523378000_12.3.e228524.28","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1007\/s10620-006-9430-8","article-title":"Hepatic glycogenosis: an underrecognized source of abnormal liver function tests?","volume":"52","author":"Sayuk","year":"2007","journal-title":"Dig Dis Sci"},{"key":"2025082622523378000_12.3.e228524.29","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1097\/01.tp.0000239510.27872.07","article-title":"Complete reversal of glycogen hepatopathy with pancreas transplantation: two cases","volume":"83","author":"Fridell","year":"2007","journal-title":"Transplantation"},{"key":"2025082622523378000_12.3.e228524.30","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1111\/j.1464-5491.2007.02085.x","article-title":"Hepatic glycogenosis: abnormal liver function tests in Type 1 diabetes","volume":"24","author":"Cuthbertson","year":"2007","journal-title":"Diabet Med"},{"key":"2025082622523378000_12.3.e228524.31","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2007.11.002"},{"key":"2025082622523378000_12.3.e228524.32","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1016\/j.jpeds.2010.06.018","article-title":"Hepatic glycogenosis in an adolescent with diabetes","volume":"157","author":"Bua","year":"2010","journal-title":"J Pediatr"},{"key":"2025082622523378000_12.3.e228524.33","doi-asserted-by":"crossref","first-page":"469","DOI":"10.2169\/internalmedicine.45.1548","article-title":"Rapid onset of glycogen storage hepatomegaly in a type-2 diabetic patient after a massive dose of long-acting insulin and large doses of glucose","volume":"45","author":"Tsujimoto","year":"2006","journal-title":"Intern Med"},{"key":"2025082622523378000_12.3.e228524.34","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1159\/000437048","article-title":"Glycogenic hepatopathy: thinking outside the box","volume":"9","author":"Parmar","year":"2015","journal-title":"Case Rep Gastroenterol"},{"key":"2025082622523378000_12.3.e228524.35","doi-asserted-by":"crossref","unstructured":"Hamed AE , Elwan N , Naguib M , et al . Diabetes association with liver diseases: an overview for clinicians. Endocr Metab Immune Disord Drug Targets 2018.doi:10.2174\/1871530318666181116111945","DOI":"10.2174\/1871530318666181116111945"},{"key":"2025082622523378000_12.3.e228524.36","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.11.004"},{"key":"2025082622523378000_12.3.e228524.37","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1002\/hep.23402","article-title":"The bright liver of glycogenic hepatopathy","volume":"51","author":"Sweetser","year":"2010","journal-title":"Hepatology"},{"key":"2025082622523378000_12.3.e228524.38","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1507\/endocrj.EJ12-0081","article-title":"A case of glycogenic hepatopathy developed in a patient with new-onset fulminant type 1 diabetes: the role of image modalities in diagnosing hepatic glycogen deposition including gradient-dual-echo MRI","volume":"59","author":"Murata","year":"2012","journal-title":"Endocr J"},{"key":"2025082622523378000_12.3.e228524.39","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1111\/ped.12235","article-title":"Glycogenic hepatopathy and non-alcoholic fatty liver disease in type 1 diabetes patients","volume":"55","author":"Saikusa","year":"2013","journal-title":"Pediatr Int"},{"key":"2025082622523378000_12.3.e228524.40","doi-asserted-by":"crossref","first-page":"903","DOI":"10.5604\/01.3001.0012.7189","article-title":"Computed tomography and magnetic resonance imaging features of primary and secondary hepatic glycogenosis","volume":"17","author":"Chen","year":"2018","journal-title":"Ann Hepatol"},{"key":"2025082622523378000_12.3.e228524.41","doi-asserted-by":"crossref","first-page":"172","DOI":"10.4254\/wjh.v10.i2.172","article-title":"Glycogenic hepatopathy: a narrative review","volume":"10","author":"Sherigar","year":"2018","journal-title":"World J Hepatol"},{"key":"2025082622523378000_12.3.e228524.42","doi-asserted-by":"crossref","first-page":"318","DOI":"10.2350\/10-07-0876-CR.1","article-title":"Dumping syndrome, a cause of acquired glycogenic hepatopathy","volume":"14","author":"Resnick","year":"2011","journal-title":"Pediatr Dev Pathol"},{"key":"2025082622523378000_12.3.e228524.43","doi-asserted-by":"crossref","first-page":"e15","DOI":"10.1016\/j.clinre.2015.05.001","article-title":"Hepatic glycogen deposition in a patient with anorexia nervosa and persistently abnormal transaminase levels","volume":"40","author":"Kransdorf","year":"2016","journal-title":"Clin Res Hepatol Gastroenterol"},{"key":"2025082622523378000_12.3.e228524.44","doi-asserted-by":"crossref","first-page":"673","DOI":"10.17235\/reed.2016.3934\/2015","article-title":"Glycogenic hepatopathy in young adults: a case series","volume":"108","author":"Silva","year":"2016","journal-title":"Rev Esp Enferm Dig"},{"key":"2025082622523378000_12.3.e228524.45","doi-asserted-by":"crossref","first-page":"7651387","DOI":"10.1155\/2017\/7651387","article-title":"Glycogenic hepatopathy: resolution with minimal glucose control","volume":"2017","author":"Chandel","year":"2017","journal-title":"Case Reports Hepatol"},{"key":"2025082622523378000_12.3.e228524.46","doi-asserted-by":"crossref","first-page":"89","DOI":"10.15537\/smj.2017.1.15934","article-title":"Glycogenic hepatopathy, an underdiagnosed cause of relapsing hepatitis in uncontrolled type 1 diabetes mellitus","volume":"38","author":"Al Sarkhy","year":"2017","journal-title":"Saudi Med J"},{"key":"2025082622523378000_12.3.e228524.47","doi-asserted-by":"crossref","first-page":"A23","DOI":"10.1016\/j.cgh.2017.02.004","article-title":"Acute and relapsing hepatitis caused by glycogenic hepatopathy","volume":"15","author":"Shah","year":"2017","journal-title":"Clin Gastroenterol Hepatol"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2018-228524","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T05:52:43Z","timestamp":1756273963000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2018-228524"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":47,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2019,3,20]]},"published-print":{"date-parts":[[2019,3]]}},"alternative-id":["10.1136\/bcr-2018-228524"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2018-228524","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2019,3]]}}}