{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:21:00Z","timestamp":1790745660214,"version":"4.1.0"},"reference-count":18,"publisher":"BMJ","issue":"8","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2019,7,19]]},"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:p>Sexual side-effects are common among those using antipsychotic medication and may result in poor compliance and reduced quality of life. Retrograde ejaculation (RE) has been described occurring with a number of antipsychotic medications (thioridazine, risperidone, iloperidone and clozapine) but there are no guidelines regarding management of antipsychotic-associated RE. Imipramine has been suggested as a treatment for antipsychotic-associated RE in one small study of patients prescribed thioridazine and a case series of patients prescribed iloperidone. Quetiapine is a commonly used antipsychotic and is thought to be associated with less sexual side-effects relative to other antipsychotic medications. This case report describes a 25-year-old man with first episode psychosis who developed RE during treatment with quetiapine which improved with low-dose imipramine. This is the first description of RE occurring with quetiapine and successful treatment of quetiapine-associated RE with imipramine.<\/jats:p>","DOI":"10.1136\/bcr-2018-228539","type":"journal-article","created":{"date-parts":[[2019,8,5]],"date-time":"2019-08-05T06:15:11Z","timestamp":1564985711000},"page":"e228539","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":13,"title":["Retrograde ejaculation associated with quetiapine and treatment with low-dose imipramine"],"prefix":"10.1136","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5095-4150","authenticated-orcid":false,"given":"Matthew","family":"Roughley","sequence":"first","affiliation":[{"name":"City and Hackney Centre for Mental Health, East London NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Lyall","sequence":"additional","affiliation":[{"name":"John Howard Centre, East London NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2019,8,4]]},"reference":[{"key":"2025082801524588000_12.8.e228539.1","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2014-006135","article-title":"Prescribing of antipsychotics in UK primary care: a cohort study","volume":"4","author":"Marston","year":"2014","journal-title":"BMJ Open"},{"key":"2025082801524588000_12.8.e228539.2","unstructured":"Joint Formulary Committee.. 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