{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T08:10:07Z","timestamp":1756368607873,"version":"3.44.0"},"reference-count":22,"publisher":"BMJ","issue":"10","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2019,9,13]]},"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:p>Iron isomaltose is considered as safe form of iron with no test dose recommended. Here, we are describing the case of a patient who experienced allergic reaction with this formulation of iron. A 35-year-old South Asian woman experienced allergic reaction, she had mild wheeze on examination of chest. She was given intranasal oxygen at 2\u2009L\/min. She was given intravenous acetaminophen 1\u2009g for pain relief, 45.4\u2009mg intravenous chlorphenaramine and intravenous 100\u2009mg hydrocortisone. Within half an hour, all her symptoms improved and her hypoxia resolved. Her chest wheezing also disappeared. Iron isomaltose, although relatively safe, can cause allergic reaction. Intravenous iron can cause allergic reaction therefore it should be administered at the facility where trained staff is present so that necessary treatment can be given in case of hypersensitivity reaction.<\/jats:p>","DOI":"10.1136\/bcr-2018-228596","type":"journal-article","created":{"date-parts":[[2019,10,16]],"date-time":"2019-10-16T06:28:38Z","timestamp":1571207318000},"page":"e228596","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Iron III isomaltose induced hypersensitivity reaction"],"prefix":"10.1136","volume":"12","author":[{"given":"Mahreen","family":"Muzammil","sequence":"first","affiliation":[{"name":"Department of Pharmacy Services, Aga Khan University, Karachi, Pakistan"},{"name":"Department of Pharmacology, Faculty of Pharmacy, Jinnah University for Women, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kashif","family":"Aziz","sequence":"additional","affiliation":[{"name":"Department of Medicine, Aga Khan University, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Ehteram ul Haq","sequence":"additional","affiliation":[{"name":"Post Graduate Medical Education, Aga Khan University, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nosheen","family":"Nasir","sequence":"additional","affiliation":[{"name":"Department of Medicine, Aga Khan University, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,10,15]]},"reference":[{"key":"2025082800284575000_12.10.e228596.1","doi-asserted-by":"publisher","DOI":"10.1093\/ndtplus\/sfr042"},{"key":"2025082800284575000_12.10.e228596.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2011.03.016"},{"key":"2025082800284575000_12.10.e228596.3","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfv096"},{"key":"2025082800284575000_12.10.e228596.4","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1111\/vox.12278","article-title":"Intravenous iron isomaltoside 1000 (Monofer\u00ae) reduces postoperative anaemia in preoperatively non-anaemic patients undergoing elective or subacute coronary artery bypass graft, valve replacement or a combination thereof: a randomized double-blind placebo-controlled clinical trial (the protect trial)","volume":"109","author":"Johansson","year":"2015","journal-title":"Vox Sang"},{"key":"2025082800284575000_12.10.e228596.5","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2010.1.338"},{"key":"2025082800284575000_12.10.e228596.6","article-title":"Pharmacokinetics of iron isomaltoside 1000 in patients with inflammatory bowel disease","volume":"6","author":"Nordfjeld","year":"2012","journal-title":"Drug Des Devel Ther"},{"key":"2025082800284575000_12.10.e228596.7","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-07-3046"},{"key":"2025082800284575000_12.10.e228596.8","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1111\/ijlh.12132","article-title":"Empty iron stores in children and young adults--the diagnostic accuracy of MCV, MCH, and MCHC","volume":"36","author":"\u00c5sberg","year":"2014","journal-title":"Int J Lab Hematol"},{"key":"2025082800284575000_12.10.e228596.9","unstructured":"Sarma PR . 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