{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T15:06:05Z","timestamp":1775919965809,"version":"3.50.1"},"reference-count":19,"publisher":"BMJ","issue":"8","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2019,7,31]]},"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:p>A 5-year-old girl presented to paediatric emergency with fever and seizures for a short duration. At first, meningitis was suspected and management was started empirically. There was no improvement in the clinical condition of the patient and investigations revealed spontaneous intracranial haemorrhage (ICH) secondary to factor XIII deficiency. The child was transfused cryoprecipitate and managed conservatively for ICH. She became asymptomatic and was kept on monthly cryoprecipitate transfusions. This case report summarises factor XIII deficiency in ICH which was not suspected initially, but diagnosed later on after CT scan head and factor XIII assay. This report also highlights events occurring during its management.<\/jats:p>","DOI":"10.1136\/bcr-2018-228682","type":"journal-article","created":{"date-parts":[[2019,8,26]],"date-time":"2019-08-26T13:55:15Z","timestamp":1566827715000},"page":"e228682","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Factor XIII deficiency with intracranial haemorrhage"],"prefix":"10.1136","volume":"12","author":[{"given":"Muzamil","family":"Ejaz","sequence":"first","affiliation":[{"name":"Pediatrics, Dow Medical College, Dow University of Health Sciences, Dr Ruth KM Pfau Civil Hospital, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayesha","family":"Saleem","sequence":"additional","affiliation":[{"name":"Pediatrics, Dow Medical College, Dow University of Health Sciences, Dr Ruth KM Pfau Civil Hospital, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nimrah","family":"Ali","sequence":"additional","affiliation":[{"name":"Pediatrics, Dow Medical College, Dow University of Health Sciences, Dr Ruth KM Pfau Civil Hospital, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fizza","family":"Tariq","sequence":"additional","affiliation":[{"name":"Pediatrics, Dow Medical College, Dow University of Health Sciences, Dr Ruth KM Pfau Civil Hospital, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,8,26]]},"reference":[{"key":"2025082712404274000_12.8.e228682.1","unstructured":"Gober-Wilcox J , Crookston K . 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