{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T15:10:01Z","timestamp":1756307401217,"version":"3.44.0"},"reference-count":9,"publisher":"BMJ","issue":"9","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2019,9,18]]},"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:p>A 57-year-old man with a known anterior mediastinal mass presented with abdominal distension, jaundice, and signs of urinary and bowel obstruction. Labs revealed leukocytosis, transaminitis, direct hyperbilirubinaemia and elevated levels of alkaline phosphatase, lactate dehydrogenase and uric acid. Subsequent imaging revealed the anterior mediastinal mass and diffuse liver lesions consistent with metastatic disease. MRI of the spine and brain were negative for metastases. Liver biopsy and immunohistochemistry revealed basaloid squamous cell carcinoma of thymic origin. Treatment with capecitabine was initiated but was complicated by worsening liver and kidney failure. Eventually, due to continued worsening of the patient\u2019s condition and minimal treatment response, capecitabine was stopped during cycle 1 and the patient was discharged to inpatient hospice with comfort care. In this case report, we highlight the presenting features, imaging findings and management of a patient with metastatic thymic carcinoma.<\/jats:p>","DOI":"10.1136\/bcr-2018-228860","type":"journal-article","created":{"date-parts":[[2019,9,30]],"date-time":"2019-09-30T14:45:29Z","timestamp":1569854729000},"page":"e228860","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Metastatic basaloid squamous cell carcinoma of thymic origin"],"prefix":"10.1136","volume":"12","author":[{"given":"Samuel","family":"Phen","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Florida College of Medicine, Gainesville, Florida, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3457-9327","authenticated-orcid":false,"given":"Mindy X","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Florida, Gainesville, Florida, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Kelling","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Florida, Gainesville, Florida, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gurjaspreet K","family":"Bhattal","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Florida, Gainesville, Florida, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,9,30]]},"reference":[{"key":"2025082707355802000_12.9.e228860.1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181a2443b"},{"key":"2025082707355802000_12.9.e228860.2","doi-asserted-by":"crossref","first-page":"bcr2015211374","DOI":"10.1136\/bcr-2015-211374","article-title":"Thymic carcinoma presenting as atypical chest pain","volume":"2015","author":"Siddiqui","year":"2015","journal-title":"BMJ Case Rep"},{"key":"2025082707355802000_12.9.e228860.3","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1007\/s00595-009-4203-6","article-title":"Thymic basaloid carcinoma with pleural dissemination that developed after a curative resection: report of a case","volume":"40","author":"Sakakura","year":"2010","journal-title":"Surg Today"},{"key":"2025082707355802000_12.9.e228860.4","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/S0003-4975(02)03555-5","article-title":"Thymic basaloid carcinoma with hepatic metastasis","volume":"74","author":"Matsuo","year":"2002","journal-title":"Ann Thorac Surg"},{"key":"2025082707355802000_12.9.e228860.5","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1080\/003130200104439","article-title":"Basaloid squamous carcinoma in the liver","volume":"32","author":"Bastiaan de Boer","year":"2000","journal-title":"Pathology"},{"key":"2025082707355802000_12.9.e228860.6","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1007\/s00595-005-3072-x","article-title":"Basaloid carcinoma of the thymus: report of a case","volume":"36","author":"Morisaki","year":"2005","journal-title":"Surg Today"},{"key":"2025082707355802000_12.9.e228860.7","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1097\/COC.0000000000000400","article-title":"Capecitabine and celecoxib as a promising therapy for thymic neoplasms","volume":"41","author":"Wood","year":"2018","journal-title":"Am J Clin Oncol"},{"key":"2025082707355802000_12.9.e228860.8","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.2010.511610"},{"key":"2025082707355802000_12.9.e228860.9","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1097\/MCG.0000000000000888","article-title":"Celecoxib- induced liver injury","volume":"52","author":"Mukthinuthalapati","year":"2018","journal-title":"Journal of Clinical Gastroenterology"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2018-228860","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T14:36:05Z","timestamp":1756305365000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2018-228860"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":9,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2019,9,30]]},"published-print":{"date-parts":[[2019,9]]}},"alternative-id":["10.1136\/bcr-2018-228860"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2018-228860","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2019,9]]}}}