{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T23:09:46Z","timestamp":1779318586229,"version":"3.51.4"},"reference-count":14,"publisher":"BMJ","issue":"5","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2019,4,26]]},"published-print":{"date-parts":[[2019,5,11]]},"abstract":"<jats:p>Hydroxychloroquine (HCQ) is largely prescribed as an immunomodulator to prevent systemic diseases flares in patients with systemic lupus erythematous, rheumatoid arthritis, Sjogren\u2019s disease. Among reported side effects, HCQ can accumulate in lysosomes and induced phospholipidosis. Here, we report an HCQ-induced podocytopathy mimicking Fabry disease (FD). They share the same histological lesions: cytoplasmic vacuolisation of the podocytes and zebra bodies on light and electronic microscopy. FD has been ruled out by measuring enzymatic activity and genetic test. The persistence of proteinuria after immunological remission of a systemic disease treated with HCQ could suggest this HCQ-induced podocytopathy.<\/jats:p>","DOI":"10.1136\/bcr-2018-228876","type":"journal-article","created":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T07:56:29Z","timestamp":1557820589000},"page":"e228876","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":18,"title":["Hydroxychloroquine-induced podocytopathy mimicking Fabry disease"],"prefix":"10.1136","volume":"12","author":[{"given":"Justine","family":"Serre","sequence":"first","affiliation":[{"name":"Nephrology, Assistance Publique - H\u00f4pitaux de Paris, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Buob","sequence":"additional","affiliation":[{"name":"Pathology, Assistance Publique - H\u00f4pitaux de paris, Paris, France"},{"name":"UMRS 1155, Sorbonne Universit\u00e9 INSERM, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Jacques","family":"Boffa","sequence":"additional","affiliation":[{"name":"Nephrology, Assistance Publique - H\u00f4pitaux de Paris, Paris, France"},{"name":"UMRS 1155, Sorbonne Universit\u00e9 INSERM, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,5,13]]},"reference":[{"key":"2025082804460371000_12.5.e228876.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lpm.2014.03.007"},{"key":"2025082804460371000_12.5.e228876.2","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1186\/s12882-017-0571-0","article-title":"Ultrastructural deposits appearing as \"zebra bodies\" in renal biopsy: Fabry disease?- comparative case reports","volume":"18","author":"de Menezes Neves","year":"2017","journal-title":"BMC Nephrol"},{"key":"2025082804460371000_12.5.e228876.3","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sft089"},{"key":"2025082804460371000_12.5.e228876.4","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2006.05.034"},{"key":"2025082804460371000_12.5.e228876.5","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800344"},{"key":"2025082804460371000_12.5.e228876.6","doi-asserted-by":"publisher","DOI":"10.1053\/hupa.2003.36"},{"key":"2025082804460371000_12.5.e228876.7","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfm462"},{"key":"2025082804460371000_12.5.e228876.8","first-page":"2591","article-title":"Hydroxychloroquine-induced lipidosis of the kidney mimicking Fabry disease: a case report","volume":"9","author":"Zhao","year":"2016","journal-title":"Int J Clin Exp Pathol"},{"key":"2025082804460371000_12.5.e228876.9","doi-asserted-by":"crossref","first-page":"146","DOI":"10.3109\/01913123.2012.751950","article-title":"Hydroxychloroquine-induced phospholipidosis in a case of SLE: the wolf in zebra clothing","volume":"37","author":"Khubchandani","year":"2013","journal-title":"Ultrastruct Pathol"},{"key":"2025082804460371000_12.5.e228876.10","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1080\/01913123.2016.1272664","article-title":"Hydroxychloroquine-induced phospholipidosis in a renal transplant patient","volume":"41","author":"Brealey","year":"2017","journal-title":"Ultrastruct Pathol"},{"key":"2025082804460371000_12.5.e228876.11","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.kint.2018.02.003","article-title":"Hydroxychloroquine-induced mimic of renal Fabry\u00a0disease","volume":"94","author":"Sperati","year":"2018","journal-title":"Kidney Int"},{"issue":"Suppl 2","key":"2025082804460371000_12.5.e228876.12","doi-asserted-by":"crossref","first-page":"S134","DOI":"10.1097\/01.ASN.0000016684.07368.75","article-title":"Renal pathology in Fabry disease","volume":"13","author":"Alroy","year":"2002","journal-title":"J Am Soc Nephrol"},{"key":"2025082804460371000_12.5.e228876.13","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.11781017"},{"key":"2025082804460371000_12.5.e228876.14","unstructured":"Ferluga D . Nephropathy in Fabry disease and iatrogenic phospholipidosis mimicking Fabry disease\u00a0Nephropathology Working Group. 2010 www.nephropathology-esp.org."}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2018-228876","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T11:46:10Z","timestamp":1756381570000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2018-228876"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,11]]},"references-count":14,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2019,5,13]]},"published-print":{"date-parts":[[2019,5,11]]}},"alternative-id":["10.1136\/bcr-2018-228876"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2018-228876","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,11]]}}}