{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T09:36:21Z","timestamp":1771493781407,"version":"3.50.1"},"reference-count":18,"publisher":"BMJ","issue":"6","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2019,5,29]]},"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:p>Eosinophilic granulomatosis with polyangiitis (EGPA), previously called Churg-Strauss Syndrome, is a systemic autoimmune disease that is usually associated with asthma and eosinophilia. It is a rare condition associated with antineutrophil cytoplasmic antibodies (ANCA). We report a case of a 52-year-old Nigerian woman who presented with bilateral leg swelling with multiple ulcers, background history of allergic rhinitis and chronic sinusitis since adolescence. There were also associated symptoms of peripheral neuropathy, weight loss, peripheral blood eosinophilia and positive perinuclear ANCA and she was previously managed for rheumatoid arthritis and asthma. She fulfilled the American College of Rheumatology criteria for EGPA and was treated with glucocorticoids and methotrexate which led to significant improvement of her symptoms.<\/jats:p>","DOI":"10.1136\/bcr-2018-228901","type":"journal-article","created":{"date-parts":[[2019,6,19]],"date-time":"2019-06-19T06:45:11Z","timestamp":1560926711000},"page":"e228901","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Eosinophilic granulomatosis with polyangiitis in a Nigerian woman"],"prefix":"10.1136","volume":"12","author":[{"given":"Ngozi Lina","family":"Ekeigwe","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Federal Medical Center Owerri, Owerri, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5132-7941","authenticated-orcid":false,"given":"Olufemi","family":"Adelowo","sequence":"additional","affiliation":[{"name":"Department of Medicine, Lagos State University Teaching Hospital, Lagos, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ehiaghe Lonia","family":"Anaba","sequence":"additional","affiliation":[{"name":"Department of Medicine, Lagos State University Teaching Hospital, Lagos, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hakeem","family":"Olaosebikan","sequence":"additional","affiliation":[{"name":"Department of Medicine, Lagos State University Teaching Hospital, Lagos, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,6,18]]},"reference":[{"key":"2025082711115701000_12.6.e228901.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2014.12.004"},{"key":"2025082711115701000_12.6.e228901.2","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.1002\/art.40313","article-title":"The Epidemiology of Antineutrophil Cytoplasmic Autoantibody- Associated Vasculitis in Olmsted County, Minnesota (USA): a 20 year population based study","volume":"69","author":"Berti","year":"2017","journal-title":"Arthritis Rheum"},{"key":"2025082711115701000_12.6.e228901.3","first-page":"277","article-title":"Allergic granulomatosis, allergic angiitis, and periarteritis nodosa","volume":"27","author":"Churg","year":"1951","journal-title":"Am J Pathol"},{"key":"2025082711115701000_12.6.e228901.4","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780330806"},{"key":"2025082711115701000_12.6.e228901.5","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1007\/s11926-018-0711-y","article-title":"Vasculitis in Africa","volume":"20","author":"Genga","year":"2018","journal-title":"Curr Rheumatol Rep"},{"key":"2025082711115701000_12.6.e228901.6","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198403000-00001"},{"key":"2025082711115701000_12.6.e228901.7","doi-asserted-by":"crossref","first-page":"72","DOI":"10.5152\/TurkThoracJ.2017.16040","article-title":"Clinical and Serological Features of Eosinophilic and Vasculitic Phases of Eosinophilic Granulomatosis with Poliangiitis: a Case Series of 15 Patients","volume":"18","author":"Y\u0131lmaz","year":"2017","journal-title":"Turk Thorac J"},{"key":"2025082711115701000_12.6.e228901.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2010.05.003"},{"key":"2025082711115701000_12.6.e228901.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2013.03.003"},{"key":"2025082711115701000_12.6.e228901.10","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3988\/jcn.2017.13.1.77","article-title":"Clinical Characteristics and Treatment Response of Peripheral Neuropathy in the Presence of Eosinophilic Granulomatosis with Polyangiitis (Churg-Strauss Syndrome): Experience at a Single Tertiary Center","volume":"13","author":"Cho","year":"2017","journal-title":"J Clin Neurol"},{"key":"2025082711115701000_12.6.e228901.11","unstructured":"Puechal M , Ludici M , Ponte C . Anca-associated vasculitides and polyarteritisnodosa. In: Johannes WJ , Doherty M , Van Laar J , Cimmino M , Liote F , et al . eds. Eular textbook on RheumaticDiseases. 2nd edn. London: BMJ publishing group, 2016:732."},{"key":"2025082711115701000_12.6.e228901.12","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000015"},{"key":"2025082711115701000_12.6.e228901.13","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e328333390b"},{"key":"2025082711115701000_12.6.e228901.14","doi-asserted-by":"publisher","DOI":"10.1002\/art.37721"},{"key":"2025082711115701000_12.6.e228901.15","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s12865-017-0234-8","article-title":"Rheumatoid factor is correlated with disease activity and inflammatory markers in antineutrophil cytoplasmic antibody-associated vasculitis","volume":"18","author":"Watanabe","year":"2017","journal-title":"BMC Immunol"},{"key":"2025082711115701000_12.6.e228901.16","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0b013e318205a4c6"},{"key":"2025082711115701000_12.6.e228901.17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2015.04.022"},{"key":"2025082711115701000_12.6.e228901.18","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-201531"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2018-228901","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T18:12:04Z","timestamp":1756318324000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2018-228901"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":18,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2019,6,18]]},"published-print":{"date-parts":[[2019,6]]}},"alternative-id":["10.1136\/bcr-2018-228901"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2018-228901","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6]]}}}