{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T16:10:03Z","timestamp":1756311003759,"version":"3.44.0"},"reference-count":18,"publisher":"BMJ","issue":"7","funder":[{"name":"Vall d\u2019Hebron Institute of Research"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2019,6,17]]},"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:p>Paraneoplastic syndromes (PS) are a rare presentation of cancer, most commonly associated with small cell lung cancer (SCLC), breast cancer and haematologic malignancies. The diagnosis of PS is challenging because it could affect multiple organ systems and it may present before the tumour is visible by imaging. We report a malignant tumour diagnosed in a male patient who referred long-term paraesthesia and proximal muscle strength loss. After ruling out common causes of polyneuropathy, the anti-SOX1 antibody gave light to the diagnosis. A pulmonary opacity in the upper right lobe was observed in the chest X-ray and a pulmonary tumour was later confirmed by CT scan. The biopsy of the cervical lymphadenopathy determined an SCLC, which caused a PS called Lambert-Eaton myasthenic syndrome (LEMS). Our case raises awareness of a rare PS presentation, which can be diagnosed by specific antibodies, allowing early diagnosis and treatment of lung cancer.<\/jats:p>","DOI":"10.1136\/bcr-2018-228916","type":"journal-article","created":{"date-parts":[[2019,7,17]],"date-time":"2019-07-17T05:55:14Z","timestamp":1563342914000},"page":"e228916","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["A rare case of long-term paraesthesia diagnosed as a paraneoplastic syndrome by anti-SOX1 antibody determination"],"prefix":"10.1136","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8492-5195","authenticated-orcid":false,"given":"Oriol","family":"Mirallas","sequence":"first","affiliation":[{"name":"Internal Medicine Department, Hospital Vall d\u2019Hebron, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuria","family":"Rial","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Hospital Vall d\u2019Hebron, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berta","family":"Mart\u00edn-Cullell","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesus","family":"Recio-Iglesias","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Hospital Vall d\u2019Hebron, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,7,16]]},"reference":[{"issue":"2 Neuro-oncology","key":"2025082708412380000_12.7.e228916.1","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1212\/01.CON.0000464180.89580.88","article-title":"Paraneoplastic disorders","volume":"21","author":"Lancaster","year":"2015","journal-title":"Continuum"},{"key":"2025082708412380000_12.7.e228916.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2010.07.005"},{"key":"2025082708412380000_12.7.e228916.3","unstructured":"Alarc\u00f3n I , Gonz\u00e1lez C . 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