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Further imaging following cyberknife radiotherapy to new brain metastases demonstrated widespread metastatic visceral disease. Twelve cycles of carboplatin and capecitabine failed to halt disease progression. In February 2017, she commenced pembrolizumab, achieving an excellent response and currently has no clinical or radiological evidence of disease. Given the unusual behaviour of her cancer, a histopathological review was requested. The diagnosis was revised to that of porocarcinoma (PC). This represents the first documented case of PC treated with immunotherapy. As of March 2019, the patient remains free of disease.<\/jats:p>","DOI":"10.1136\/bcr-2018-228917","type":"journal-article","created":{"date-parts":[[2019,9,6]],"date-time":"2019-09-06T05:05:38Z","timestamp":1567746338000},"page":"e228917","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":39,"title":["Metastatic porocarcinoma achieving complete radiological and clinical response with pembrolizumab"],"prefix":"10.1136","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5904-5586","authenticated-orcid":false,"given":"Karla A","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Twin Research, King\u2019s College London, London, UK"},{"name":"The Royal Marsden NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margherita","family":"Cioni","sequence":"additional","affiliation":[{"name":"Department of Dermatology, San Martino Policlinic Hospital, Genoa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alistair","family":"Robson","sequence":"additional","affiliation":[{"name":"LD Path Group, London, UK"},{"name":"Department of Pathology, Instituto Portugues de Oncologia de Lisboa Francisco Gentil EPE, Lisboa, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronique","family":"Bataille","sequence":"additional","affiliation":[{"name":"Kings College, London, UK"},{"name":"Dermatology, West Herts NHS Trust, Hemel Hempstead, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2019,9,5]]},"reference":[{"key":"2025082804380324000_12.9.e228917.1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1983.01650260012008"},{"key":"2025082804380324000_12.9.e228917.2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19850901)56:5<1147::AID-CNCR2820560532>3.0.CO;2-3"},{"key":"2025082804380324000_12.9.e228917.3","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1963.01590230105015"},{"key":"2025082804380324000_12.9.e228917.4","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.amsu.2017.06.027","article-title":"Porocarcinoma; presentation and management, a meta-analysis of 453 cases","volume":"20","author":"Salih","year":"2017","journal-title":"Annals of Medicine and Surgery"},{"key":"2025082804380324000_12.9.e228917.5","first-page":"107","article-title":"[Eccrine porocarcinoma. 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