{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T11:10:23Z","timestamp":1756379423303,"version":"3.44.0"},"reference-count":16,"publisher":"BMJ","issue":"7","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2019,6,9]]},"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:p>Herein we present a case of a patient with Charcot-Marie-Tooth (CMT) disease who was diagnosed with locally invasive nasopharyngeal carcinoma. In the context of CMT, the use of standard platinum-based radio-sensitising chemotherapy would have been neurotoxic and is contraindicated in patients with CMT. However, no alternate antineoplastic treatment strategies for patients with CMT have been described in the literature. In this case, an innovative approach was taken using radical radiotherapy concurrently with the biological agent cetuximab. The patient did not suffer any neurotoxicity, though he did experience several expected toxicities commonly associated with this regimen. The patient nonetheless completed treatment and has experienced an excellent response both clinically and radiographically and remains disease free.<\/jats:p>","DOI":"10.1136\/bcr-2018-228956","type":"journal-article","created":{"date-parts":[[2019,7,15]],"date-time":"2019-07-15T08:25:23Z","timestamp":1563179123000},"page":"e228956","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Successful treatment of nasopharyngeal cancer using radiotherapy with concurrent cetuximab in a patient with Charcot-Marie-Tooth disease"],"prefix":"10.1136","volume":"12","author":[{"given":"Alexandra Nicoleta","family":"Budure","sequence":"first","affiliation":[{"name":"Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Winquist","sequence":"additional","affiliation":[{"name":"London Health Sciences Centre, London, Ontario, Canada"},{"name":"Department of Oncology, Western University, London, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Palma","sequence":"additional","affiliation":[{"name":"London Health Sciences Centre, London, Ontario, Canada"},{"name":"Department of Oncology, Western University, London, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rohann Jonathan Mark","family":"Correa","sequence":"additional","affiliation":[{"name":"London Health Sciences Centre, London, Ontario, Canada"},{"name":"Department of Oncology, Western University, London, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,7,15]]},"reference":[{"key":"2025082803394876000_12.7.e228956.1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/123.7.1516"},{"key":"2025082803394876000_12.7.e228956.2","unstructured":"Bird TD . et al Charcot-Marie-Tooth Neuropathy Type 1. In: Adam M , Ardinger H , Pagon R , Al E , . eds. GeneReviews, 1998."},{"key":"2025082803394876000_12.7.e228956.3","unstructured":"Bird TD . Charcot-Marie-Tooth Neuropathy Type 2. In: Adam M , Ardinger H , Pagon R , eds. GeneReviews. Seattle WA, 2016."},{"key":"2025082803394876000_12.7.e228956.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2005.11.014"},{"key":"2025082803394876000_12.7.e228956.5","unstructured":"National Comprehensive Cancer Network. Head and Neck Cancers. https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/head-and-neck.pdf (cited 1 Oct 2018)."},{"key":"2025082803394876000_12.7.e228956.6","first-page":"1397","article-title":"Cetuximab or Nimotuzumab Versus Cisplatin Concurrent with Radiotherapy for Local-Regionally Advanced Nasopharyngeal Carcinoma: a Meta-analysis","volume":"19","author":"Liang","year":"2018","journal-title":"Asian Pac J Cancer Prev"},{"key":"2025082803394876000_12.7.e228956.7","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24265"},{"key":"2025082803394876000_12.7.e228956.8","first-page":"787","article-title":"Low dose vincristine-induced severe polyneuropathy in a Hodgkin lymphoma patient: a case report (vincristine-induced severe polyneuropathy)","volume":"31","author":"Cil","year":"2009","journal-title":"JPediatrHematolOncol"},{"key":"2025082803394876000_12.7.e228956.9","first-page":"165","article-title":"Charcot-Marie-Tooth disease type I diagnosed in a 5-year-old boy after vincristine neurotoxicity, resulting in maternal diagnosis","volume":"99","author":"Olek","year":"1999","journal-title":"J Am Osteopath Assoc"},{"key":"2025082803394876000_12.7.e228956.10","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-200304000-00010"},{"key":"2025082803394876000_12.7.e228956.11","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1097\/MPH.0b013e31816624a4","article-title":"Severe neurotoxicities in a case of Charcot-Marie-Tooth disease type 2 caused by vincristine for acute lymphoblastic leukemia","volume":"30","author":"Nishikawa","year":"2008","journal-title":"J Pediatr Hematol Oncol"},{"key":"2025082803394876000_12.7.e228956.12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2015.06.056"},{"key":"2025082803394876000_12.7.e228956.13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0162755"},{"key":"2025082803394876000_12.7.e228956.14","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.12545"},{"key":"2025082803394876000_12.7.e228956.15","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1002\/cpt.562","article-title":"Modeling Drug-Induced Neuropathy Using Human iPSCs for Predictive Toxicology","volume":"101","author":"Ohara","year":"2017","journal-title":"Clin Pharmacol Ther"},{"key":"2025082803394876000_12.7.e228956.16","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/j.clineuro.2010.07.005","article-title":"Chronic immune-mediated demyelinating polyneuropathy in the setting of cetuximab treatment","volume":"112","author":"Beydoun","year":"2010","journal-title":"Clin Neurol Neurosurg"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2018-228956","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T10:39:59Z","timestamp":1756377599000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2018-228956"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":16,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2019,7,15]]},"published-print":{"date-parts":[[2019,7]]}},"alternative-id":["10.1136\/bcr-2018-228956"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2018-228956","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2019,7]]}}}