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The rare presentation and non-specific symptom constellation contributed to delayed institution of the appropriated treatment regimen at a point where multiorganic involvement was irreversible leading to death only 2\u2009months after the first manifestation. The presented case reminds us of the importance of always keeping in mind this rarer cause of ischaemic stroke since an early diagnosis remains the key to a more hopeful prognosis.<\/jats:p>","DOI":"10.1136\/bcr-2018-228979","type":"journal-article","created":{"date-parts":[[2019,6,29]],"date-time":"2019-06-29T12:54:07Z","timestamp":1561812847000},"page":"e228979","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Ischaemic stroke as the initial manifestation of systemic amyloidosis"],"prefix":"10.1136","volume":"12","author":[{"given":"Patr\u00edcia","family":"Marques","sequence":"first","affiliation":[{"name":"Neurology, Centro Hospitalar e Universitario de Coimbra EPE, Coimbra, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Beato-Coelho","sequence":"additional","affiliation":[{"name":"Neurology, Centro Hospitalar e Universitario de Coimbra EPE, Coimbra, 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