{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T15:44:06Z","timestamp":1759938246393,"version":"3.44.0"},"reference-count":13,"publisher":"BMJ","issue":"4","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2019,3,15]]},"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:p>Carteolol, a non-selective beta-antagonist with a potential risk of severe bronchial constriction in patients with asthma, is one of the most commonly prescribed medication for managing ocular pressure in glaucoma. We present a case of a 24-year-old woman with a history of atopy but no known asthma who presented an insidious onset of clinical manifestations compatible with drug-induced asthma after the initiation of carteolol for ocular hypertension control. The patient developed progressive chest tightness and dyspnoea for 2\u2009months before the pulmonary function test revealed a positive bronchoprovocation response. She reported significant improvement of respiratory symptoms within 2\u2009weeks after the discontinuation of carteolol, and a negative provocation response was later confirmed by repeat pulmonary function test. In conclusion, eye drops with non-selective beta-antagonising effect can induce asthmatic symptoms in patients without a previous diagnosis of asthma and should be administered with caution in patients with associated risk factors.<\/jats:p>","DOI":"10.1136\/bcr-2019-229343","type":"journal-article","created":{"date-parts":[[2019,4,4]],"date-time":"2019-04-04T19:25:18Z","timestamp":1554405918000},"page":"e229343","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Insidious-onset, non-wheezing carteolol-induced asthma in an atopic patient without asthma history"],"prefix":"10.1136","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9435-746X","authenticated-orcid":false,"given":"Jo-Hsuan","family":"Wu","sequence":"first","affiliation":[{"name":"National Taiwan University College of Medicine, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5324-8523","authenticated-orcid":false,"given":"Jih-Shuin","family":"Jerng","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chien-Chia","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,4,4]]},"reference":[{"key":"2025082709082479000_12.4.e229343.1","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.2147\/OPTH.S118409","article-title":"Systemic side effects of eye drops: a pharmacokinetic perspective","volume":"10","author":"Farkouh","year":"2016","journal-title":"Clin Ophthalmol"},{"key":"2025082709082479000_12.4.e229343.2","doi-asserted-by":"crossref","first-page":"379","DOI":"10.18176\/jiaci.0099","article-title":"Serious Adverse Reaction to Timolol Eye Drops in a 7-Year-Old Boy With Glaucoma and Asthma","volume":"26","author":"Cano-Mollinedo","year":"2016","journal-title":"J Investig Allergol Clin Immunol"},{"key":"2025082709082479000_12.4.e229343.3","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1111\/bcp.13006","article-title":"Respiratory effect of beta-blocker eye drops in asthma: population-based study and meta-analysis of clinical trials","volume":"82","author":"Morales","year":"2016","journal-title":"Br J Clin Pharmacol"},{"key":"2025082709082479000_12.4.e229343.4","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.55.7.562"},{"key":"2025082709082479000_12.4.e229343.5","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1038\/s41588-018-0121-0","article-title":"A genome-wide cross-trait analysis from UK Biobank highlights the shared genetic architecture of asthma and allergic diseases","volume":"50","author":"Zhu","year":"2018","journal-title":"Nat Genet"},{"key":"2025082709082479000_12.4.e229343.6","first-page":"91","article-title":"The link between allergic rhinitis and asthma: a role for antileukotrienes?","volume":"15","author":"Kim","year":"2008","journal-title":"Can Respir J"},{"key":"2025082709082479000_12.4.e229343.7","doi-asserted-by":"crossref","first-page":"753","DOI":"10.3390\/molecules21060753","article-title":"Hyper IgE in Childhood Eczema and Risk of Asthma in Chinese Children","volume":"21","author":"Ng","year":"2016","journal-title":"Molecules"},{"key":"2025082709082479000_12.4.e229343.8","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1111\/all.12798","article-title":"IgE antibodies in relation to prevalence and multimorbidity of eczema, asthma, and rhinitis from birth to adolescence","volume":"71","author":"Ballardini","year":"2016","journal-title":"Allergy"},{"key":"2025082709082479000_12.4.e229343.9","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.jaip.2017.10.028","article-title":"Atopy Is Associated with Age at Asthma Onset in Elderly Patients","volume":"6","author":"Agondi","year":"2018","journal-title":"J Allergy Clin Immunol Pract"},{"key":"2025082709082479000_12.4.e229343.10","doi-asserted-by":"publisher","DOI":"10.1089\/jop.1993.9.373"},{"key":"2025082709082479000_12.4.e229343.11","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1080\/02770900500370981","article-title":"The assessment of validity of different asthma diagnostic tools in adults","volume":"42","author":"Yurdakul","year":"2005","journal-title":"J Asthma"},{"key":"2025082709082479000_12.4.e229343.12","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3003.1999.14a12.x"},{"key":"2025082709082479000_12.4.e229343.13","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.jaci.2013.03.040","article-title":"Can an airway challenge test predict respiratory diseases? 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