{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T08:19:36Z","timestamp":1761293976289,"version":"3.44.0"},"reference-count":7,"publisher":"BMJ","issue":"8","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2019,8,7]]},"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:p>We report a case of primary pulmonary cryptococcosis in a 59-year-old female patient with a history of systemic lupus erythematosus, interstitial lung disease and glaucoma. She presented with a cough, severe fatigue, unintentional weight loss, shortness of breath (increase in home oxygen use from baseline) and pleuritic chest pain of 2\u2009months duration. During these 2\u2009months, her symptoms had worsened despite multiple hospital visits, empirical antibiotics and empirical increase of her steroid dosage. Cytopathology of the bronchoalveolar lavage fluid showed yeast cells with narrow-based budding and grew <jats:italic>Cryptococcus neoformans<\/jats:italic> on fungal culture. She was treated with oral fluconazole 400\u2009mg\/day for 6\u2009months with an improvement in cough, decrease in shortness of breath (return to baseline oxygen use) and resolution of pleuritic chest pain.<\/jats:p>","DOI":"10.1136\/bcr-2019-229403","type":"journal-article","created":{"date-parts":[[2019,8,26]],"date-time":"2019-08-26T13:55:16Z","timestamp":1566827716000},"page":"e229403","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Pulmonary cryptococcosis complicating interstitial lung disease in a patient with systemic lupus erythematosus"],"prefix":"10.1136","volume":"12","author":[{"given":"Rahul","family":"Gaiba","sequence":"first","affiliation":[{"name":"Mysore Medical College and Research Institute, Mysore, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward","family":"O\u2019Neill","sequence":"additional","affiliation":[{"name":"Tampa General Hospital, Tampa, Florida, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seetha","family":"Lakshmi","sequence":"additional","affiliation":[{"name":"Internal Medicine, Morsani College of Medicine , University fo South Florida, Tampa, Florida, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,8,26]]},"reference":[{"key":"2025082623264735000_12.8.e229403.1","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1186\/s12879-017-2865-z","article-title":"Clinical features of pulmonary cryptococcosis among patients with different levels of peripheral blood CD4+ T lymphocyte counts","volume":"17","author":"He","year":"2017","journal-title":"BMC Infect Dis"},{"key":"2025082623264735000_12.8.e229403.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2017.04.007"},{"key":"2025082623264735000_12.8.e229403.3","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1007\/s11046-017-0233-6","article-title":"Cryptococcus gattii infection presenting as an aggressive lung mass","volume":"183","author":"Zheng","year":"2018","journal-title":"Mycopathologia"},{"key":"2025082623264735000_12.8.e229403.4","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200907-063AL"},{"key":"2025082623264735000_12.8.e229403.5","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/23.4.810"},{"key":"2025082623264735000_12.8.e229403.6","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1055\/s-0035-1562895","article-title":"Pulmonary cryptococcosis","volume":"36","author":"Chang","year":"2015","journal-title":"Semin Respir Crit Care Med"},{"key":"2025082623264735000_12.8.e229403.7","doi-asserted-by":"crossref","first-page":"2687","DOI":"10.1177\/0300060518769541","article-title":"Clinical features and radiological characteristics of pulmonary cryptococcosis","volume":"46","author":"Deng","year":"2018","journal-title":"J Int Med Res"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2019-229403","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T06:26:52Z","timestamp":1756276012000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2019-229403"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":7,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2019,8,26]]},"published-print":{"date-parts":[[2019,8]]}},"alternative-id":["10.1136\/bcr-2019-229403"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2019-229403","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2019,8]]}}}