{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:16:35Z","timestamp":1791306995216,"version":"4.3.1"},"reference-count":20,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2020,2,10]]},"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:p>We report a case of Beh\u00e7et\u2019s disease in a 9-year-old boy from Greece, presenting with a history of recurrent ulceration of the oral cavity. Following inspection of the oral cavity, which revealed lesions on both the upper and lower labial mucosa, as well as a large ulcer on the apex of the tongue, the diagnosis of Beh\u00e7et\u2019s disease was immediately suspected. The diagnosis was confirmed using the International Criteria for Beh\u00e7et\u2019s Disease. Nevertheless, as multiple diseases can cause recurrent oral aphthosis, an extensive differential diagnosis was made, and pertinent tests were undertaken to exclude other causes of oral ulceration. The approach to a patient with Beh\u00e7et\u2019s disease, as well as its various clinical presentations and complications, is discussed.<\/jats:p>","DOI":"10.1136\/bcr-2019-229527","type":"journal-article","created":{"date-parts":[[2020,2,27]],"date-time":"2020-02-27T04:14:25Z","timestamp":1582776865000},"page":"e229527","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Beh\u00e7et\u2019s disease presenting as recurrent oral aphthosis in a 9-year-old boy from Greece"],"prefix":"10.1136","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2712-5909","authenticated-orcid":false,"given":"George","family":"Panos","sequence":"first","affiliation":[{"name":"Infectious Diseases Section, University General Hospital of Patras, Patras, Achaia, Greece"},{"name":"Internal Medicine, University Cyprus School of Medicine, Nicosia, Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6245-1569","authenticated-orcid":false,"given":"Loukas","family":"Kakoullis","sequence":"additional","affiliation":[{"name":"Internal Medicine, Nicosia General Hospital, University of Cyprus Medical School, Nicosia, Cyprus"},{"name":"Respiratory Medicine, University General Hospital of Patras, Patras, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stylianos","family":"Louppides","sequence":"additional","affiliation":[{"name":"Internal Medicine, Nicosia General Hospital, University of Cyprus Medical School, Nicosia, Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Emmanuil","sequence":"additional","affiliation":[{"name":"Biochemical Laboratory, University General Hospital of Patras, Patras, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2020,2,26]]},"reference":[{"key":"2025082802512259000_13.2.e229527.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2007.01.009"},{"key":"2025082802512259000_13.2.e229527.2","article-title":"Histopathological evaluation of Beh\u00e7et's disease and identification of new skin lesions","volume":"2012","author":"G\u00fcnd\u00fcz","year":"2012","journal-title":"Patholog Res Int"},{"key":"2025082802512259000_13.2.e229527.3","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12107"},{"key":"2025082802512259000_13.2.e229527.4","first-page":"1078","article-title":"Criteria for diagnosis of Beh\u00e7et's disease. International Study Group for Beh\u00e7et's disease","volume":"335","year":"1990","journal-title":"Lancet"},{"key":"2025082802512259000_13.2.e229527.5","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1111\/1346-8138.13381","article-title":"Beh\u00e7et's disease: a comprehensive review with a focus on epidemiology, etiology and clinical features, and management of mucocutaneous lesions","volume":"43","author":"Alpsoy","year":"2016","journal-title":"J Dermatol"},{"key":"2025082802512259000_13.2.e229527.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.cden.2013.12.002"},{"key":"2025082802512259000_13.2.e229527.7","first-page":"26","article-title":"Recurrent aphthous stomatitis: a review","volume":"10","author":"Edgar","year":"2017","journal-title":"J Clin Aesthet Dermatol"},{"key":"2025082802512259000_13.2.e229527.8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/art.24270","article-title":"Patient-Reported outcomes for arthritis: time to focus on personal life impact measures?","volume":"61","author":"Sanderson","year":"2009","journal-title":"Arthritis Rheum"},{"key":"2025082802512259000_13.2.e229527.9","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ker428"},{"key":"2025082802512259000_13.2.e229527.10","doi-asserted-by":"crossref","first-page":"564","DOI":"10.12968\/denu.2015.42.6.564","article-title":"Management of recurrent aphthous stomatitis in children","volume":"42","author":"Montgomery-Cranny","year":"2015","journal-title":"Dent Update"},{"key":"2025082802512259000_13.2.e229527.11","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(98)70368-3"},{"key":"2025082802512259000_13.2.e229527.12","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/820710","article-title":"Gender differences in Beh\u00e7et's disease associated uveitis","volume":"2014","author":"Ucar-Comlekoglu","year":"2014","journal-title":"J Ophthalmol"},{"key":"2025082802512259000_13.2.e229527.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2007.10.452"},{"key":"2025082802512259000_13.2.e229527.14","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1007\/s00415-013-7209-3","article-title":"Diagnosis and management of Neuro-Beh\u00e7et's disease: international consensus recommendations","volume":"261","author":"Kalra","year":"2014","journal-title":"J Neurol"},{"key":"2025082802512259000_13.2.e229527.15","doi-asserted-by":"publisher","DOI":"10.1016\/S1297-319X(03)00076-9"},{"key":"2025082802512259000_13.2.e229527.16","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.ajem.2004.05.009","article-title":"Hemoptysis caused by Hughes-Stovin syndrome","volume":"23","author":"Tsai","year":"2005","journal-title":"Am J Emerg Med"},{"key":"2025082802512259000_13.2.e229527.17","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.143.4.821"},{"key":"2025082802512259000_13.2.e229527.18","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1097\/MAJ.0b013e318068d7c3","article-title":"An unusual vascular involvement in a patient with Behcet's disease: renal artery stenosis","volume":"334","author":"Toprak","year":"2007","journal-title":"Am J Med Sci"},{"key":"2025082802512259000_13.2.e229527.19","doi-asserted-by":"crossref","unstructured":"Khalid U , Saleem T . Hughes-Stovin syndrome, 2011: 1\u201311.","DOI":"10.1186\/1750-1172-6-15"},{"key":"2025082802512259000_13.2.e229527.20","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2018-213225"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2019-229527","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T09:51:31Z","timestamp":1756374691000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2019-229527"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":20,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2020,2,26]]},"published-print":{"date-parts":[[2020,2]]}},"alternative-id":["10.1136\/bcr-2019-229527"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2019-229527","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2]]}}}