{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T11:40:37Z","timestamp":1777894837149,"version":"3.51.4"},"reference-count":9,"publisher":"BMJ","issue":"8","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2019,8,3]]},"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:p>Phaeochromocytomas are rare neuroendocrine tumours (NET) with malignant behaviour in about 10% of cases. The median time from the diagnosis of primary tumour and bone metastasis is 3.4 years. We report a case of a 66-year-old woman presenting with a hypertensive crisis and back pain. She has a history of a phaeochromocytoma completely resected 18 years before. MRI showed a neoplastic mass on the 10th thoracic vertebra (T10), with fracture and spinal cord compression. The CT-guided biopsy was consistent with metastasis of a NET. Therefore, she was treated with phenoxybenzamine and external beam radiotherapy. However, clinical (dorsal pain) and biochemical (ie, elevated chromogranin A) signs suggested persistent disease and the patient was treated with iodine-131 metaiodobenzylguanidine and T10 kyphoplasty. After 8\u2009years, she remains clinically stable. This case demonstrates that phaeochromocytomas may reveal malignant behaviour several years after diagnosis, and therefore patients should be maintained under long term surveillance.<\/jats:p>","DOI":"10.1136\/bcr-2019-229621","type":"journal-article","created":{"date-parts":[[2019,8,22]],"date-time":"2019-08-22T05:16:32Z","timestamp":1566450992000},"page":"e229621","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Thoracic spine metastasis presenting 18 years after complete resection of a phaeochromocytoma"],"prefix":"10.1136","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1513-2722","authenticated-orcid":false,"given":"L\u00facia","family":"Fadiga","sequence":"first","affiliation":[{"name":"Endocrinology, Diabetes and Metabolism Department, Centro Hospitalar e Universitario de Coimbra EPE, Coimbra, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joana","family":"Saraiva","sequence":"additional","affiliation":[{"name":"Endocrinology, Diabetes and Metabolism Department, Centro Hospitalar e Universitario de Coimbra EPE, Coimbra, Portugal"},{"name":"Universidade de Coimbra Faculdade de Medicina, Coimbra, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"Paiva","sequence":"additional","affiliation":[{"name":"Endocrinology, Diabetes and Metabolism Department, Centro Hospitalar e Universitario de Coimbra EPE, Coimbra, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Carrilho","sequence":"additional","affiliation":[{"name":"Endocrinology, Diabetes and Metabolism Department, Centro Hospitalar e Universitario de Coimbra EPE, Coimbra, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,8,21]]},"reference":[{"key":"2025082623301988000_12.8.e229621.1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-1498"},{"key":"2025082623301988000_12.8.e229621.2","doi-asserted-by":"crossref","first-page":"vii131","DOI":"10.1093\/annonc\/mds231","article-title":"Adrenal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up","volume":"23 Suppl 7","author":"Berruti","year":"2012","journal-title":"Ann Oncol"},{"key":"2025082623301988000_12.8.e229621.3","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-16-0033"},{"key":"2025082623301988000_12.8.e229621.4","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1097\/MED.0000000000000330","article-title":"Malignant pheochromocytoma-paraganglioma: pathogenesis, TNM staging, and current clinical trials","volume":"24","author":"Roman-Gonzalez","year":"2017","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"key":"2025082623301988000_12.8.e229621.5","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-4231"},{"key":"2025082623301988000_12.8.e229621.6","doi-asserted-by":"publisher","DOI":"10.1530\/EC-14-0119"},{"key":"2025082623301988000_12.8.e229621.7","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1097\/RLU.0b013e31828e98f0","article-title":"Pheochromocytoma presenting with remote bony recurrence twenty years after initial surgery: detection with 68Ga-DOTANOC PET\/CT","volume":"39","author":"Parida","year":"2014","journal-title":"Clin Nucl Med"},{"key":"2025082623301988000_12.8.e229621.8","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2012-0293"},{"key":"2025082623301988000_12.8.e229621.9","unstructured":"Jimenez C , Libutti SK , Landry CS , et al ; Adrenal-neuroendocrine tumors. In: Amin MB , Edge S , Greene F , eds. AJCC cancer staging manual. Eighth edition. Chicago: ed American Joint Committee on Cancer\/Springer, 2017:919\u201327."}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2019-229621","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T06:30:30Z","timestamp":1756276230000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2019-229621"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":9,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2019,8,21]]},"published-print":{"date-parts":[[2019,8]]}},"alternative-id":["10.1136\/bcr-2019-229621"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2019-229621","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8]]}}}