{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T10:32:44Z","timestamp":1779186764119,"version":"3.51.4"},"reference-count":16,"publisher":"BMJ","issue":"6","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2019,5,24]]},"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:p>Parvovirus infection is usually asymptomatic especially in immunocompetent adults. When symptomatic it can range from mild to life threatening depending on the patient\u2019s age and comorbidities. We report a case of a 40-year-old male patient with parvovirus infection who presented a purpuric rash in distal extremities, acute kidney injury, type II mixed cryoglobulinaemia and hypocomplementaemia. His renal biopsy showed a mesangioproliferative glomerulonephritis with positive immunoreactivity to C3, IgM and C1q. Parvovirus B19 was detected in the biopsy tissue by PCR. He was treated with prednisolone with total remission after 1\u2009month. We discuss the diagnosis of kidney lesion due to parvovirus in an immunocompetent person, which is a very rare condition and its association with the cryoglobulinaemia diagnosis.<\/jats:p>","DOI":"10.1136\/bcr-2019-229622","type":"journal-article","created":{"date-parts":[[2019,6,8]],"date-time":"2019-06-08T12:25:12Z","timestamp":1559996712000},"page":"e229622","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Parvoviral infection with systemic impact and renal consequences"],"prefix":"10.1136","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5682-3116","authenticated-orcid":false,"given":"Filipe Santos","family":"Mira","sequence":"first","affiliation":[{"name":"Nephrology, Centro Hospitalar e Universitario de Coimbra EPE, Coimbra, Portugal"},{"name":"Medical Sciences, Universidade de Coimbra Faculdade de Medicina, Coimbra, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Marques","sequence":"additional","affiliation":[{"name":"Medical Sciences, Universidade de Coimbra Faculdade de Medicina, Coimbra, Portugal"},{"name":"Internal Medicine, Centro Hospitalar e Universitario de Coimbra EPE, Coimbra, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V\u00edtor","family":"Sousa","sequence":"additional","affiliation":[{"name":"Anatomical Pathology, Coimbra\u2019s Medical College, Coimbra, Portugal"},{"name":"Anatomical Pathology, Coimbra\u2019s Hospital and Universitary Center, Coimbra, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9lia","family":"Nogueira","sequence":"additional","affiliation":[{"name":"Anatomical Pathology and Molecular Pathology Institute, Universidade de Coimbra Faculdade de Medicina, Coimbra, Portugal"},{"name":"Center for Neuroscience and Cell Biology, Universidade de Coimbra Faculdade de Medicina, Coimbra, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Garcia","sequence":"additional","affiliation":[{"name":"Medical Sciences, Universidade de Coimbra Faculdade de Medicina, Coimbra, Portugal"},{"name":"Internal Medicine, Centro Hospitalar e Universitario de Coimbra EPE, Coimbra, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Alves","sequence":"additional","affiliation":[{"name":"Nephrology, Centro Hospitalar e Universitario de Coimbra EPE, Coimbra, Portugal"},{"name":"Medical Sciences, Universidade de Coimbra Faculdade de Medicina, Coimbra, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,6,8]]},"reference":[{"key":"2025082722035132000_12.6.e229622.1","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.ad.2014.06.004","article-title":"Estudio retrospectivo de 49 casos de infecci\u00f3n aguda por parvovirus B19 en adultos","volume":"106","author":"Rodr\u00edguez Bandera","year":"2015","journal-title":"Actas Dermo-Sifiliogr\u00e1ficas"},{"key":"2025082722035132000_12.6.e229622.2","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.medcli.2013.11.029","article-title":"[Parvovirus B19 disease in immunocompetent adults. 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