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The patient was a poor responder to systemic corticosteroids, anti-inflammatories and anticonvulsant therapy. Her unique presentation gives insight into a rare but debilitating disorder and the potential link between amyloidosis and other disease processes.<\/jats:p>","DOI":"10.1136\/bcr-2019-229677","type":"journal-article","created":{"date-parts":[[2019,10,23]],"date-time":"2019-10-23T15:35:55Z","timestamp":1571844955000},"page":"e229677","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Severe hand pain as an extracardiac manifestation of transthyretin amyloidosis"],"prefix":"10.1136","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6702-3352","authenticated-orcid":false,"given":"Sneha N","family":"Patel","sequence":"first","affiliation":[{"name":"Rheumatology, Montefiore Hospital and Medical Center, Bronx, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sai Krishna","family":"Koyoda","sequence":"additional","affiliation":[{"name":"Internal Medicine, Monmouth Medical Center, Long Branch, New Jersey, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Pathology, Montefiore Hospital and Medical Center, Bronx, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bibi","family":"Ayesha","sequence":"additional","affiliation":[{"name":"Rheumatology, Montefiore Hospital and Medical Center, Bronx, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,10,23]]},"reference":[{"key":"2025082707393157000_12.10.e229677.1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2014-308724"},{"key":"2025082707393157000_12.10.e229677.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2008.02.011"},{"key":"2025082707393157000_12.10.e229677.3","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2000.3203"},{"key":"2025082707393157000_12.10.e229677.4","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.2174\/092986712800269317","article-title":"Diagnosis and therapeutic approaches to transthyretin amyloidosis","volume":"19","author":"Ueda","year":"2012","journal-title":"Curr Med Chem"},{"key":"2025082707393157000_12.10.e229677.5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1805689"},{"key":"2025082707393157000_12.10.e229677.6","doi-asserted-by":"publisher","DOI":"10.1021\/bi00173a029"},{"key":"2025082707393157000_12.10.e229677.7","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(87)90265-6"},{"key":"2025082707393157000_12.10.e229677.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.05.020"},{"key":"2025082707393157000_12.10.e229677.9","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(85)91948-5"},{"key":"2025082707393157000_12.10.e229677.10","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199702000-00007"},{"key":"2025082707393157000_12.10.e229677.11","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.berh.2012.07.003","article-title":"Osteo-Articular manifestations of amyloidosis","volume":"26","author":"M'bapp\u00e9","year":"2012","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"2025082707393157000_12.10.e229677.12","doi-asserted-by":"crossref","first-page":"28","DOI":"10.3109\/13506129.2013.862229","article-title":"Amyloid arthropathy associated with multiple myeloma: polyarthritis without synovial infiltration of CD20+ or CD38+ cells","volume":"21","author":"Pessler","year":"2014","journal-title":"Amyloid"},{"key":"2025082707393157000_12.10.e229677.13","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1002\/art.39178","article-title":"Transthyretin deposition in articular cartilage: a novel mechanism in the pathogenesis of osteoarthritis","volume":"67","author":"Akasaki","year":"2015","journal-title":"Arthritis Rheumatol"},{"key":"2025082707393157000_12.10.e229677.14","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3780116"},{"key":"2025082707393157000_12.10.e229677.15","doi-asserted-by":"crossref","unstructured":"Goffin YA . 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