{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T11:35:36Z","timestamp":1761824136392,"version":"3.44.0"},"reference-count":15,"publisher":"BMJ","issue":"7","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2019,6,17]]},"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:p>Cowden syndrome (CS) is a rare disorder characterised by multiple non-cancerous, tumour-like growths called hamartomas. The syndrome is associated with the development of cancer of the breast, endometrium, kidneys, skin and rarely the brain. We report a rare case of symptomatic cardiac haemangioma in a patient with CS. A 54-year-old woman with CS presented with dyspnoea and orthopnoea in the setting of cardiac tamponade. Echocardiography revealed a large haemopericardium and tamponade physiology, secondary to a pericardial mass. The patient underwent urgent cardiopulmonary bypass with removal of the mass. Histopathology confirmed a benign cavernous haemangioma. We postulate that tumours involving the heart\/pericardium may be an additional manifestation of CS. This case further highlights the necessity to consider pericardial\/cardiac manifestations in patients with hamartomatous syndromes who present with cardiorespiratory symptoms, so that opportunistic investigation and treatment may be instituted.<\/jats:p>","DOI":"10.1136\/bcr-2019-229741","type":"journal-article","created":{"date-parts":[[2019,7,9]],"date-time":"2019-07-09T06:10:49Z","timestamp":1562652649000},"page":"e229741","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Left atrial cavernous haemangioma presenting with cardiac tamponade in a patient with Cowden syndrome"],"prefix":"10.1136","volume":"12","author":[{"given":"Alexandra","family":"Drucker","sequence":"first","affiliation":[{"name":"Department of Anaesthesia, Austin Health, Heidelberg, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pathology, Austin Health, Heidelberg, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siven","family":"Seevanayagam","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Austin Health, Heidelberg, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7403-7680","authenticated-orcid":false,"given":"Laurence","family":"Weinberg","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Austin Health, Heidelberg, Victoria, Australia"},{"name":"Surgery and Anaesthesia Preoperative Pain Medicine Unit, University of Melbourne, Melbourne, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,7,8]]},"reference":[{"key":"2025082801275555000_12.7.e229741.1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5200289"},{"key":"2025082801275555000_12.7.e229741.2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/8.8.1461"},{"key":"2025082801275555000_12.7.e229741.3","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.02.141"},{"key":"2025082801275555000_12.7.e229741.4","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1093\/jnen\/64.4.341","article-title":"Lhermitte-Duclos disease: a report of 31 cases with immunohistochemical analysis of the PTEN\/AKT\/mTOR pathway","volume":"64","author":"Abel","year":"2005","journal-title":"J Neuropathol Exp Neurol"},{"key":"2025082801275555000_12.7.e229741.5","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djt277"},{"key":"2025082801275555000_12.7.e229741.6","unstructured":"Kumar V , Abbas AK , Fausto N , et al . 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