{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:32:33Z","timestamp":1777725153454,"version":"3.51.4"},"reference-count":14,"publisher":"BMJ","issue":"7","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2019,7,12]]},"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:p>A 72-year-old woman presented with nephrotic proteinuria and moderate haematuria. Renal pathology was compatible with immunotactoid glomerulopathy (ITG), for which there is no consensus for appropriate therapy. We, therefore, postponed immunosuppressive therapy. After 4 years, the patient\u2019s renal function started to decline and renal pathology was re-evaluated, revealing a pathological change from mesangial proliferative glomerulonephritis to endocapillary proliferative glomerulonephritis. Treatment with oral prednisolone (30 mg\/day) was initiated. Within 5 weeks, complete remission of proteinuria was obtained (proteinuria 6.02 g\/gCr to 0.12 g\/gCr), and the patient\u2019s renal function stabilised. Generally, responsiveness to immunosuppressive therapy is poor in patients with ITG, and the present case represented a very rare clinical course. Some previous cases have indicated susceptibility to the therapy, regardless of the severity of renal damage. As a possible distinct entity that determines susceptibility to immunosuppressive therapy, we suggest the presence of a latent lymphoproliferative disease with no significant haematological symptoms.<\/jats:p>","DOI":"10.1136\/bcr-2019-229751","type":"journal-article","created":{"date-parts":[[2019,7,26]],"date-time":"2019-07-26T09:05:15Z","timestamp":1564131915000},"page":"e229751","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Case of immunotactoid glomerulopathy showing high responsiveness to steroids therapy despite severe pathological features"],"prefix":"10.1136","volume":"12","author":[{"given":"Atsuki","family":"Ohashi","sequence":"first","affiliation":[{"name":"Nephrology, Yokohama City Minato Red Cross Hospital, Yokohama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiro","family":"Kumagai","sequence":"additional","affiliation":[{"name":"Pathology, Yokohama City Minato Red Cross Hospital, Yokohama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyotaka","family":"Nagahama","sequence":"additional","affiliation":[{"name":"Pathology, Kyorin University, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hajime","family":"Fujisawa","sequence":"additional","affiliation":[{"name":"Nephrology, Yokohama City Minato Red Cross Hospital, Yokohama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,7,26]]},"reference":[{"key":"2025082723143215000_12.7.e229751.1","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1097\/00005792-198507000-00004","article-title":"Immunotactoid glomerulopathy","volume":"64","author":"Korbet","year":"1985","journal-title":"Medicine"},{"key":"2025082723143215000_12.7.e229751.2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000013397.06964.19"},{"key":"2025082723143215000_12.7.e229751.3","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2002.00628.x"},{"key":"2025082723143215000_12.7.e229751.4","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(12)70138-5"},{"key":"2025082723143215000_12.7.e229751.5","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.02980316"},{"key":"2025082723143215000_12.7.e229751.6","doi-asserted-by":"crossref","first-page":"575","DOI":"10.3109\/01913128009140563","article-title":"The quarterly case: nephrotic syndrome in a middle-aged man","volume":"1","author":"Schwartz","year":"1980","journal-title":"Ultrastruct Pathol"},{"key":"2025082723143215000_12.7.e229751.7","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2003.00853.x"},{"key":"2025082723143215000_12.7.e229751.8","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfs348"},{"key":"2025082723143215000_12.7.e229751.9","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.1998.t01-1-00094.x"},{"key":"2025082723143215000_12.7.e229751.10","first-page":"591","article-title":"Fibrillary glomerulopathy: defining the disease spectrum","volume":"2","author":"D\u2019Agati","year":"1991","journal-title":"J.Am.Soc.Nephrol"},{"key":"2025082723143215000_12.7.e229751.11","doi-asserted-by":"crossref","first-page":"F785","DOI":"10.1152\/ajprenal.2000.279.4.F785","article-title":"CD2AP is expressed with nephrin in developing podocytes and is found widely in mature kidney and elsewhere","volume":"279","author":"Li","year":"2000","journal-title":"Am J Physiol Renal Physiol"},{"key":"2025082723143215000_12.7.e229751.12","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2000.2147"},{"key":"2025082723143215000_12.7.e229751.13","doi-asserted-by":"publisher","DOI":"10.1126\/science.286.5438.312"},{"key":"2025082723143215000_12.7.e229751.14","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1007\/s10157-009-0166-6","article-title":"A case of immunotactoid glomerulopathy exhibiting nephrotic syndrome successfully treated with corticosteroids and antihypertensive therapy","volume":"13","author":"Kinomura","year":"2009","journal-title":"Clin Exp Nephrol"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2019-229751","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T06:14:41Z","timestamp":1756361681000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2019-229751"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":14,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2019,7,26]]},"published-print":{"date-parts":[[2019,7]]}},"alternative-id":["10.1136\/bcr-2019-229751"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2019-229751","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7]]}}}