{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T17:52:39Z","timestamp":1781027559585,"version":"3.54.1"},"reference-count":37,"publisher":"BMJ","issue":"8","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2019,8,13]]},"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:p>A 45-year-old man presented with a 10-year history of relapsing oedema of the lips. Moreover, he exhibited recurrent facial nerve palsy since the age of 10 years, coeliac disease since the age of 12 years, atopic eczema, allergic rhinitis and asthma. Physical examination revealed lip swelling and lingua plicata. Thus, he presented the classic triad of Melkersson-Rosenthal syndrome which includes recurrent orofacial oedema, facial nerve palsy and fissured tongue. A lip biopsy confirmed our clinical diagnosis.<\/jats:p>\n               <jats:p>This case is particularly rare, as the classic triad is seen only in a minority of the cases. Moreover, allergic and coeliac diseases were observed concomitantly. This paper illustrates a potential pathophysiological interconnection between these pathologies in which interferon gamma could play a key role. To our knowledge, this is the first case report in which Melkersson-Rosenthal syndrome has been observed concurrently with coeliac disease.<\/jats:p>","DOI":"10.1136\/bcr-2019-229857","type":"journal-article","created":{"date-parts":[[2019,8,29]],"date-time":"2019-08-29T07:34:54Z","timestamp":1567064094000},"page":"e229857","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Melkersson-Rosenthal syndrome with coeliac and allergic diseases"],"prefix":"10.1136","volume":"12","author":[{"given":"Joana Albuquerque","family":"Martins","sequence":"first","affiliation":[{"name":"Physical and Rehabilitation Medicine Department, Centro Hospitalar e Universitario de Coimbra EPE, Coimbra, Portugal"},{"name":"Faculty of Medicine, University of Coimbra, Coimbra, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ant\u00f3nio","family":"Azenha","sequence":"additional","affiliation":[{"name":"Physical and Rehabilitation Medicine Department, Centro Hospitalar e Universitario de Coimbra EPE, Coimbra, Portugal"},{"name":"Faculty of Medicine, University of Coimbra, Coimbra, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Almeida","sequence":"additional","affiliation":[{"name":"Department of Pathology, Centro Hospitalar e Universitario de Coimbra EPE, Coimbra, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o P\u00e1scoa","family":"Pinheiro","sequence":"additional","affiliation":[{"name":"Physical and Rehabilitation Medicine Department, Centro Hospitalar e Universitario de Coimbra EPE, Coimbra, Portugal"},{"name":"Faculty of Medicine, University of Coimbra, Coimbra, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2019,8,28]]},"reference":[{"key":"2025082623065268000_12.8.e229857.1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2015-210138"},{"key":"2025082623065268000_12.8.e229857.2","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/s40001-015-0192-7","article-title":"Melkersson-Rosenthal syndrome as an early manifestation of mixed connective tissue disease","volume":"20","author":"Jasinska","year":"2015","journal-title":"Eur J Med Res"},{"key":"2025082623065268000_12.8.e229857.3","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2014-204674"},{"key":"2025082623065268000_12.8.e229857.4","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-012-6603-6"},{"key":"2025082623065268000_12.8.e229857.5","doi-asserted-by":"publisher","DOI":"10.1159\/000393465"},{"key":"2025082623065268000_12.8.e229857.6","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.jocn.2012.10.009","article-title":"Melkersson-Rosenthal syndrome: a review of seven patients","volume":"20","author":"Liu","year":"2013","journal-title":"J Clin Neurosci"},{"key":"2025082623065268000_12.8.e229857.7","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1111\/j.1346-8138.1997.tb02792.x","article-title":"Melkersson-Rosenthal syndrome\u2014a challenge for dermatologists to participate in the field of oral medicine","volume":"24","author":"Hornstein","year":"1997","journal-title":"J Dermatol"},{"key":"2025082623065268000_12.8.e229857.8","doi-asserted-by":"publisher","DOI":"10.1258\/0022215021910861"},{"key":"2025082623065268000_12.8.e229857.9","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1111\/j.1346-8138.2008.00530.x","article-title":"Successful treatment of granulomatous cheilitis with roxithromycin","volume":"35","author":"Ishiguro","year":"2008","journal-title":"J Dermatol"},{"key":"2025082623065268000_12.8.e229857.10","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1159\/000247454","article-title":"Minocycline in granulomatous cheilitis: experience with 6 cases","volume":"185","author":"Veller Fornasa","year":"1992","journal-title":"Dermatology"},{"key":"2025082623065268000_12.8.e229857.11","doi-asserted-by":"crossref","unstructured":"Emiroglu N , Su O , Cengiz FP , et al . 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