{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:05:54Z","timestamp":1756339554306,"version":"3.44.0"},"reference-count":25,"publisher":"BMJ","issue":"7","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2019,6,11]]},"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:p>A 30-year-old Caucasian woman with no prior medical history presented with pedal oedema, arthralgias and abdominal pain with diarrhoea, following a respiratory infection. She had mild abdominal tenderness along with a purpuric rash on the extremities and was anaemic. Following initial workup for anaemia and rash, her condition deteriorated with renal impairment, respiratory failure and seizures necessitating ventilatory support, dialysis and steroids. Serologies were negative, and skin biopsy showed leucocytoclastic vasculitis without vascular IgA deposition, and renal biopsy showed subendothelial, mesangial deposits of IgA with C3 indicative of Henoch-Schonlein purpura (HSP). She was treated with steroids, haemodialysis and on 6-month follow-up recovered renal function. We present the case to illustrate that HSP, though rare in adults, can present with multiorgan failure, with renal, pulmonary and central nervous system involvement, and the need for early diagnosis and prompt treatment for rapid clinical recovery.<\/jats:p>","DOI":"10.1136\/bcr-2019-229939","type":"journal-article","created":{"date-parts":[[2019,7,18]],"date-time":"2019-07-18T06:55:13Z","timestamp":1563432913000},"page":"e229939","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Seizures, renal failure and acute respiratory failure: not your typical case of Henoch-Schonlein purpura"],"prefix":"10.1136","volume":"12","author":[{"given":"Subhasish","family":"Bose","sequence":"first","affiliation":[{"name":"Department of Nephrology, Lynchburg Nephrology, Lynchburg, Virginia, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samata","family":"Pathireddy","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Deaconess Health System, Evansville, Indiana, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krishna M","family":"Baradhi","sequence":"additional","affiliation":[{"name":"Department of Nephrology, University of Oklahoma School of Community Medicine, Tulsa, Oklahoma, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Narothama Reddy","family":"Aeddula","sequence":"additional","affiliation":[{"name":"Department of Medicine, Deaconess Health System, Evansville, Indiana, USA"},{"name":"Department of Medicine, Indiana University School of Medicine, Evansville, Indiana, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,7,17]]},"reference":[{"key":"2025082710450731000_12.7.e229939.1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.54.11.822"},{"key":"2025082710450731000_12.7.e229939.2","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200809020-00001"},{"key":"2025082710450731000_12.7.e229939.3","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-007-0147-0"},{"key":"2025082710450731000_12.7.e229939.4","doi-asserted-by":"publisher","DOI":"10.1097\/SMJ.0b013e3180f62d0f"},{"key":"2025082710450731000_12.7.e229939.5","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.diii.2014.02.014","article-title":"Henoch-Sch\u00f6nlein purpura in adults","volume":"95","author":"Colleter","year":"2014","journal-title":"Diagn Interv Imaging"},{"key":"2025082710450731000_12.7.e229939.6","doi-asserted-by":"crossref","first-page":"bcr-2018-227161","DOI":"10.1136\/bcr-2018-227161","article-title":"Hydralazine-associated antineutrophil cytoplasmic antibody vasculitis with pulmonary-renal syndrome","volume":"2018","author":"Aeddula","year":"2018","journal-title":"BMJ Case Rep"},{"key":"2025082710450731000_12.7.e229939.7","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.3892\/ol.2013.1274","article-title":"Adult Henoch-Sch\u00f6nlein purpura associated with small cell lung cancer: A case report and review of the literature","volume":"5","author":"Zhang","year":"2013","journal-title":"Oncol Lett"},{"key":"2025082710450731000_12.7.e229939.8","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2004.066035"},{"key":"2025082710450731000_12.7.e229939.9","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-007-0640-z"},{"key":"2025082710450731000_12.7.e229939.10","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/j.1442-200x.2005.02005.x","article-title":"Henoch-Schonlein purpura with hypocomplementemia in children","volume":"47","author":"Motoyama","year":"2005","journal-title":"Pediatr Int"},{"key":"2025082710450731000_12.7.e229939.11","unstructured":"Edelmann CM . 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