{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T16:10:04Z","timestamp":1756311004077,"version":"3.44.0"},"reference-count":8,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2020,1,8]]},"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>Neutropaenia is defined as an absolute neutrophil count (ANC) of less than 1500\u2009cells\/\u00b5L and is often divided into mild (ANC: 1000 to 1500\u2009cells\/\u00b5L), moderate (ANC: 500 to 1000\u2009cells\/\u00b5L) and severe (ANC: &gt;500\u2009cells\/\u00b5L) neutropaenia. Autoimmune neutropaenia is arguably one of the most clinically relevant forms of neutropaenia and is defined by an ANC of &lt;500\u2009cells\/\u00b5L alongside the confirmed presence of anti-neutrophil antibodies. It is a rare subset of neutropaenia boasting an incidence of just 1 in 100\u2009000 infants and is thought to be caused as a result of a \u2018surveillance escape event\u2019 of the immune system. This case report identifies key issues in the diagnosis and monitoring of paediatric patients with recurrent neutropaenia and reviews current literature relating to its management in hospital and community settings.<\/jats:p>","DOI":"10.1136\/bcr-2019-229979","type":"journal-article","created":{"date-parts":[[2020,1,22]],"date-time":"2020-01-22T05:15:55Z","timestamp":1579670155000},"page":"e229979","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Paediatric autoimmune neutropaenia"],"prefix":"10.1136","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8598-3891","authenticated-orcid":false,"given":"Joshua","family":"Michaels","sequence":"first","affiliation":[{"name":"Paediatrics, East and North Herts NHS Trust, Stevenage, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anshoo","family":"Dhelaria","sequence":"additional","affiliation":[{"name":"Paediatrics, Lister Hospital, East and North Hertfordshire NHS Trust, Stevenage, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2020,1,21]]},"reference":[{"doi-asserted-by":"publisher","key":"2025082708515526000_13.1.e229979.1","DOI":"10.1186\/ar1803"},{"doi-asserted-by":"publisher","key":"2025082708515526000_13.1.e229979.2","DOI":"10.1136\/adc.2006.094706"},{"doi-asserted-by":"publisher","key":"2025082708515526000_13.1.e229979.3","DOI":"10.1053\/j.seminhematol.2013.06.010"},{"doi-asserted-by":"publisher","key":"2025082708515526000_13.1.e229979.4","DOI":"10.1016\/j.paed.2007.05.003"},{"doi-asserted-by":"publisher","key":"2025082708515526000_13.1.e229979.5","DOI":"10.3324\/haematol.2016.142760"},{"key":"2025082708515526000_13.1.e229979.6","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1182\/blood.V91.1.181","article-title":"Diagnosis and clinical course of autoimmune neutropenia in infancy: analysis of 240 cases","volume":"91","author":"Bux","year":"1998","journal-title":"Blood"},{"key":"2025082708515526000_13.1.e229979.7","doi-asserted-by":"crossref","first-page":"e131","DOI":"10.1097\/MPH.0000000000000205","article-title":"Autoimmune neutropenia of infancy with recurrent urinary tract infections","volume":"37","author":"Kanai","year":"2015","journal-title":"J Pediatr Hematol Oncol"},{"doi-asserted-by":"publisher","key":"2025082708515526000_13.1.e229979.8","DOI":"10.1542\/pir.29-1-12"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2019-229979","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T15:52:02Z","timestamp":1756309922000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2019-229979"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":8,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,1,21]]},"published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1136\/bcr-2019-229979"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2019-229979","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2020,1]]}}}