{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T09:10:07Z","timestamp":1756285807584,"version":"3.44.0"},"reference-count":3,"publisher":"BMJ","issue":"8","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2019,7,30]]},"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:p>Good\u2019s syndrome (GS) is a rare, adult-onset combined B cell and T cell immunodeficiency with an associated thymoma. These patients have an increased risk of bacterial, fungal, viral and opportunistic infections. This report describes a 75-year-old female patient who presented with a full body rash and an anterior mediastinal mass. She underwent a biopsy of her rash and mass, which revealed erythema multiforme and WHO Type A thymoma, respectively. During her hospitalisation, she was also found to have oropharyngeal candidiasis, methicillin-susceptible <jats:italic>Staphylococcus aureus<\/jats:italic> bacteraemia and herpes simplex virus type 2 (HSV-2) skin lesions. Based on the number of infections and severity of her rash, an immunocompromised state was suspected. Immunological testing revealed a B cell and T cell deficiency as well as low serum immunoglobulins. This combination of hypogammaglobulinaemia and thymoma led to a diagnosis of GS. While there have been many case reports of GS, this is the first report of the immunodeficiency presenting with erythema multiforme.<\/jats:p>","DOI":"10.1136\/bcr-2019-229999","type":"journal-article","created":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T05:55:25Z","timestamp":1566366925000},"page":"e229999","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["A case of Good\u2019s syndrome complicated by erythema multiforme"],"prefix":"10.1136","volume":"12","author":[{"given":"Laura R","family":"Glick","sequence":"first","affiliation":[{"name":"Pritzker School of Medicine, University of Chicago, Chicago, Illinois, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William Wyatt","family":"Wilson","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Chicago, Chicago, Illinois, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Fletcher","sequence":"additional","affiliation":[{"name":"Hospital Medicine, Northwestern Memorial Hospital, Chicago, Illinois, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,8,20]]},"reference":[{"key":"2025082701400865000_12.8.e229999.1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.56.1.12"},{"key":"2025082701400865000_12.8.e229999.2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-200103000-00005"},{"key":"2025082701400865000_12.8.e229999.3","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ269"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2019-229999","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T08:40:23Z","timestamp":1756284023000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2019-229999"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":3,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2019,8,20]]},"published-print":{"date-parts":[[2019,8]]}},"alternative-id":["10.1136\/bcr-2019-229999"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2019-229999","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2019,8]]}}}