{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T06:25:18Z","timestamp":1766557518600,"version":"3.44.0"},"reference-count":8,"publisher":"BMJ","issue":"8","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2019,7,19]]},"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:p>Systemic drug exposure can produce a skin reaction consisting of symmetrical erythema involving the gluteal and intertriginous areas in the absence of systemic involvement. <jats:italic>S<\/jats:italic>ymmetrical drug-related intertriginous and flexural exanthema (SDRIFE) occurs after systemic exposure to a drug in which the patient was not previously sensitised, either in the first dose or after several doses. The mechanism of SDRIFE is unknown but is hypothesised to be the result of a delayed hypersensitivity response resulting in a cutaneous eruption some days after the exposure to the drug. The diagnosis should be clinical, based on the history and examination, but skin tests can also be performed to confirm sensitisation. But, as always, the gold-standard test is oral provocation. It is important to know this clinical entity to prevent re-exposure to the responsible allergen in the future.<\/jats:p>","DOI":"10.1136\/bcr-2019-230077","type":"journal-article","created":{"date-parts":[[2019,8,3]],"date-time":"2019-08-03T07:25:18Z","timestamp":1564817118000},"page":"e230077","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["<i>S<\/i>ymmetrical drug-related intertriginous and flexural exanthema due to clindamycin"],"prefix":"10.1136","volume":"12","author":[{"given":"Virginia","family":"Cabrera Hernandez","sequence":"first","affiliation":[{"name":"Allergy Department, Hospital Universitario Nuestra Se\u00f1ora de la Candelaria, Santa Cruz de Tenerife, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Gonzalez Afonso","sequence":"additional","affiliation":[{"name":"Allergy Department, Hospital Universitario Nuestra Se\u00f1ora de la Candelaria, Santa Cruz de Tenerife, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8964-8262","authenticated-orcid":false,"given":"Ariel","family":"Callero Viera","sequence":"additional","affiliation":[{"name":"Allergy Department, Hospital Universitario Nuestra Se\u00f1ora de la Candelaria, Santa Cruz de Tenerife, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lidon","family":"Martin-Fernandez Martin","sequence":"additional","affiliation":[{"name":"Nursing Department, Hospital Universitario Nuestra Senora de la Candelaria, Santa Cruz de Tenerife, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,8,2]]},"reference":[{"issue":"S1","key":"2025082712132332000_12.8.e230077.1","doi-asserted-by":"crossref","first-page":"A84","DOI":"10.1186\/1939-4551-8-S1-A84","article-title":"Symmetrical drug-related intertriginous and flexural exanthema (SDRIFE): two atypical case reports","volume":"8","author":"Longen","year":"2015","journal-title":"World Allergy Organ J"},{"key":"2025082712132332000_12.8.e230077.2","doi-asserted-by":"crossref","first-page":"210","DOI":"10.2165\/11318350-000000000-00000","article-title":"First case of symmetric drug-related intertriginous and flexural exanthema (sdrife) due to rivastigmine?","volume":"12","author":"Allain-Veyrac","year":"2011","journal-title":"Am J Clin Dermatol"},{"key":"2025082712132332000_12.8.e230077.3","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2004.00445.x"},{"key":"2025082712132332000_12.8.e230077.4","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3315\/jdcr.2015.1190","article-title":"Symmetrical drug-related intertriginous and flexural exanthema (Baboon syndrome) associated with infliximab","volume":"9","author":"Bulur","year":"2015","journal-title":"J Dermatol Case Rep"},{"key":"2025082712132332000_12.8.e230077.5","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1111\/cod.13084","article-title":"Symmetrical drug-related intertriginous and flexural exanthema (SDRIFE) associated with pristinamycin, secnidazole, and nefopam, with a review of the literature","volume":"79","author":"Nespoulous","year":"2018","journal-title":"Contact Dermatitis"},{"key":"2025082712132332000_12.8.e230077.6","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0b013e3283489d5f"},{"key":"2025082712132332000_12.8.e230077.7","doi-asserted-by":"crossref","first-page":"171","DOI":"10.2165\/11539080-000000000-00000","article-title":"A systematic approach to systemic contact dermatitis and symmetric drug-related intertriginous and flexural exanthema (SDRIFE)","volume":"12","author":"Winnicki","year":"2011","journal-title":"Am J Clin Dermatol"},{"key":"2025082712132332000_12.8.e230077.8","first-page":"113","article-title":"SDRIFE (baboon syndrome) due to paracetamol: case report","volume":"21","author":"Lugovi\u0107-Mihi\u0107","year":"2013","journal-title":"Acta Dermatovenerol Croat"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2019-230077","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T19:13:27Z","timestamp":1756322007000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2019-230077"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":8,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2019,8,2]]},"published-print":{"date-parts":[[2019,8]]}},"alternative-id":["10.1136\/bcr-2019-230077"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2019-230077","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2019,8]]}}}