{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T19:18:27Z","timestamp":1762543107187,"version":"3.44.0"},"reference-count":17,"publisher":"BMJ","issue":"9","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2019,7,15]]},"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:p>Though prevalent in the environment, nontuberculous mycobacteria (NTM) have been increasingly identified as pathogenic. Sporadic reports of NTM infection of cardiac implantable electronic devices (CIEDs) have appeared but remain rare. This case describes a CIED infection with <jats:italic>Mycobacterium abscessus<\/jats:italic>, the third reported case in the literature. A 63-year-old male presented with a 3-day history of drainage from his pacemaker extraction site. An aspirate grew <jats:italic>Mycobacterium abscessus<\/jats:italic>. Together with National Jewish Health, a treatment plan was developed, consisting of an induction phase with amikacin, cefoxitin and clarithromycin followed by a maintenance phase with clarithromycin and clofazimine. The clinical course was complicated by cardiac arrhythmia, abscess formation and thoracic osteomyelitis with epidural abscess. This case highlights a rare manifestation of <jats:italic>Mycobacterium abscessus<\/jats:italic> disease and suggests the need for further study. Treatment is complicated by unpredictable resistance patterns, complex antimicrobial regimens and the use of arrhythmogenic medications in patients with removed CIEDs.<\/jats:p>","DOI":"10.1136\/bcr-2019-230100","type":"journal-article","created":{"date-parts":[[2019,9,18]],"date-time":"2019-09-18T06:55:13Z","timestamp":1568789713000},"page":"e230100","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Rare case of pacemaker infection with <i>Mycobacterium abscessus<\/i>"],"prefix":"10.1136","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0807-4330","authenticated-orcid":false,"given":"Alison","family":"Radigan","sequence":"first","affiliation":[{"name":"Family and Community Medicine, Western Michigan University Homer Stryker M.D. School of Medicine, Kalamazoo, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Jevert-Eichorn","sequence":"additional","affiliation":[{"name":"Family and Community Medicine, Western Michigan University Homer Stryker M.D. School of Medicine, Kalamazoo, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,9,17]]},"reference":[{"key":"2025082801565673000_12.9.e230100.1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200604-571ST"},{"key":"2025082801565673000_12.9.e230100.2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1007463630978"},{"key":"2025082801565673000_12.9.e230100.3","doi-asserted-by":"publisher","DOI":"10.1086\/504381"},{"key":"2025082801565673000_12.9.e230100.4","first-page":"3","article-title":"Pacemaker Infections Caused by Rapidly Growing Non-Tuberculous Mycobacteria: Presentation of Three Cases and Review of the Literature","volume":"2","author":"Tejada","year":"2016","journal-title":"J Antimicrob Agents"},{"key":"2025082801565673000_12.9.e230100.5","doi-asserted-by":"publisher","DOI":"10.3201\/eid2203.150584"},{"key":"2025082801565673000_12.9.e230100.6","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1186\/s13104-016-2221-1","article-title":"Cardiac implantable electronic device infection due to mycobacterium species: A case report and review of the literature","volume":"9","author":"Al-Ghamdi","year":"2016","journal-title":"BMC Res Notes"},{"key":"2025082801565673000_12.9.e230100.7","doi-asserted-by":"crossref","first-page":"47","DOI":"10.3949\/ccjm.84.s3.05","article-title":"Cardiac implantable electronic device infection","volume":"84","author":"LAMBERT","year":"2017","journal-title":"Cleve Clin J Med"},{"key":"2025082801565673000_12.9.e230100.8","doi-asserted-by":"publisher","DOI":"10.1086\/517106"},{"key":"2025082801565673000_12.9.e230100.9","unstructured":"Kessler AT , Kourtis AP . Mycobacterium abscessus as a cause of pacemaker infection. Med Sci Monit 2004;10."},{"key":"2025082801565673000_12.9.e230100.10","doi-asserted-by":"publisher","DOI":"10.3201\/2109.141634"},{"key":"2025082801565673000_12.9.e230100.11","doi-asserted-by":"crossref","first-page":"2492-6","DOI":"10.1128\/AEM.65.6.2492-2496.1999","article-title":"Occurrence of nontuberculous mycobacteria in environmental samples","volume":"65","author":"Covert","year":"1999","journal-title":"Appl Environ Microbiol"},{"key":"2025082801565673000_12.9.e230100.12","first-page":"3122-5","article-title":"Prevalence of nontuberculous mycobacteria in water supplies of hemodialysis centers","volume":"54","author":"Carson","year":"1988","journal-title":"Appl Environ Microbiol"},{"key":"2025082801565673000_12.9.e230100.13","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.micro.52.1.453"},{"key":"2025082801565673000_12.9.e230100.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijheh.2016.12.002"},{"key":"2025082801565673000_12.9.e230100.15","doi-asserted-by":"publisher","DOI":"10.1016\/0962-8479(92)90147-C"},{"key":"2025082801565673000_12.9.e230100.16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2017.03.006"},{"key":"2025082801565673000_12.9.e230100.17","unstructured":"World Health Organization. WHO Model List of Essential Medicines. 2017. WHO Medicines web http:\/\/www. who. int\/medicines\/publications\/EML."}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2019-230100","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T08:57:05Z","timestamp":1756371425000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2019-230100"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":17,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2019,9,17]]},"published-print":{"date-parts":[[2019,9]]}},"alternative-id":["10.1136\/bcr-2019-230100"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2019-230100","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2019,9]]}}}