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This case presented with obstructive urinary symptoms with no prostate-specific antigen elevation, diagnosed with imaging, managed aggressively with robotic surgery. Detailed immunohistochemistry and pathological review suggested diagnosis as carcinosarcoma with osteosarcomatous differentiation. Very rare such cases were reported in the past with complete clinical, radiological, pathological details and managed aggressively with good outcomes. The patient is disease free after 6 months of follow-up.<\/jats:p>","DOI":"10.1136\/bcr-2019-230116","type":"journal-article","created":{"date-parts":[[2019,6,13]],"date-time":"2019-06-13T06:05:15Z","timestamp":1560405915000},"page":"e230116","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Carcinosarcoma prostate with osteosarcomatous differentiation: a rare de novo presentation"],"prefix":"10.1136","volume":"12","author":[{"given":"Sumeet","family":"Aggarwal","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Swarupa","family":"Mitra","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhinav","family":"Dewan","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Garima","family":"Durga","sequence":"additional","affiliation":[{"name":"Department of Pathology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,6,12]]},"reference":[{"key":"2025082801143304000_12.6.e230116.1","unstructured":"Bernard T , John RS , Bostwick DG . 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