{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T05:05:29Z","timestamp":1761541529219,"version":"3.44.0"},"reference-count":12,"publisher":"BMJ","issue":"10","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2019,10,10]]},"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:p>A previously healthy 8-year-old girl presented to the hospital with right periorbital and forehead swelling in the setting of a 1-week history of upper respiratory symptoms. Contrast-enhanced CT revealed pansinusitis with orbital and frontal abscesses and thrombosis of the anterior portion of the superior sagittal sinus. She was treated with surgical drainage, antibiotics and anticoagulants. After 2 days she developed cranial nerve (CN) VI palsy. Contrast-enhanced MRI revealed small epidural abscess, right-sided thrombi of the cavernous sinus, internal carotid artery and internal jugular vein, in addition to the superior sagittal sinus. Thrombophilia workup revealed heterozygosity for factor V Leiden. She underwent 6 weeks of parental antibiotic therapy, 3 months of anticoagulation therapy and 7 days of steroids. With treatment, her visual acuity returned to baseline, CN VI palsy resolved and repeat imaging showed resolution of thrombi and epidural abscess, but persistent narrowing of the internal carotid artery.<\/jats:p>","DOI":"10.1136\/bcr-2019-230159","type":"journal-article","created":{"date-parts":[[2019,10,30]],"date-time":"2019-10-30T10:25:24Z","timestamp":1572431124000},"page":"e230159","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Septic cavernous sinus thrombosis in a paediatric patient with undiagnosed thrombophilia"],"prefix":"10.1136","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1233-3254","authenticated-orcid":false,"given":"Shafee","family":"Salloum","sequence":"first","affiliation":[{"name":"Pediatric Hospital Medicine, Dayton Children's Hospital, Dayton, Ohio, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Bowens","sequence":"additional","affiliation":[{"name":"Dayton Children's Hospital, Dayton, Ohio, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordan","family":"Wright","sequence":"additional","affiliation":[{"name":"Pediatric Hematology and Oncology, Dayton Children's Hospital, Dayton, Ohio, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Ey","sequence":"additional","affiliation":[{"name":"Pediatric Radiology, Dayton Children's Hospital, Dayton, Ohio, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,10,30]]},"reference":[{"key":"2025082707051111000_12.10.e230159.1","doi-asserted-by":"publisher","DOI":"10.1258\/002221502760237920"},{"key":"2025082707051111000_12.10.e230159.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2011.09.048"},{"key":"2025082707051111000_12.10.e230159.3","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2015.29.4127"},{"key":"2025082707051111000_12.10.e230159.4","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1001\/jamaoto.2013.1369","article-title":"The significance of Streptococcus anginosus group in intracranial complications of pediatric rhinosinusitis","volume":"139","author":"Deutschmann","year":"2013","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"key":"2025082707051111000_12.10.e230159.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2005.12.001"},{"key":"2025082707051111000_12.10.e230159.6","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ijporl.2016.02.022","article-title":"Microbiology and choice of antimicrobial therapy for acute sinusitis complicated by subperiosteal abscess in children","volume":"84","author":"Brook","year":"2016","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"2025082707051111000_12.10.e230159.7","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1212\/WNL.0000000000001886","article-title":"Pediatric cavernous sinus thrombosis: a case series and review of the literature","volume":"85","author":"Smith","year":"2015","journal-title":"Neurology"},{"key":"2025082707051111000_12.10.e230159.8","first-page":"456","article-title":"Cavernous sinus thrombosis revisited","volume":"70","author":"Yarington","year":"1977","journal-title":"Proc R Soc Med"},{"key":"2025082707051111000_12.10.e230159.9","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.jaapos.2015.06.001","article-title":"Ophthalmic manifestations and outcomes after cavernous sinus thrombosis in children","volume":"19","author":"Frank","year":"2015","journal-title":"J Aapos"},{"key":"2025082707051111000_12.10.e230159.10","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0b013e31820a8364"},{"key":"2025082707051111000_12.10.e230159.11","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.913673"},{"key":"2025082707051111000_12.10.e230159.12","doi-asserted-by":"publisher","DOI":"10.1097\/GIM.0b013e3181faa0f2"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2019-230159","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T14:05:17Z","timestamp":1756303517000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2019-230159"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":12,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2019,10,30]]},"published-print":{"date-parts":[[2019,10]]}},"alternative-id":["10.1136\/bcr-2019-230159"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2019-230159","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2019,10]]}}}