{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:03:24Z","timestamp":1787065404049,"version":"build-2736575974"},"reference-count":19,"publisher":"BMJ","issue":"9","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2019,8,27]]},"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:p>Small cell carcinoma of the urinary bladder (SCCB) is an extremely rare but aggressive tumour constituting less than 0.7% of all urinary bladder tumours. It is often misdiagnosed as transitional cell carcinoma, owing to the similarities in presentation. Diagnosis of SCCB is based on the WHO criteria for small cell lung carcinoma. A 58-year-old man who had presented with haematuria and burning micturition for 3 months was initially diagnosed as high-grade muscle-invasive urothelial carcinoma based on the TURBT specimen. The patient was put on neoadjuvant chemotherapy, but presented again with haematuria and back pain after 3 months. Imaging studies showed a lesion in the posterolateral wall of the urinary bladder, along with partial collapse and anterior wedging of L1 vertebra. He underwent TURBT, and on the basis of histopathology and immunohistochemistry, a diagnosis of primary SCCB bladder with vertebral metastasis was made.<\/jats:p>","DOI":"10.1136\/bcr-2019-230185","type":"journal-article","created":{"date-parts":[[2019,9,30]],"date-time":"2019-09-30T15:35:26Z","timestamp":1569857726000},"page":"e230185","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":11,"title":["Primary small cell carcinoma of the urinary bladder"],"prefix":"10.1136","volume":"12","author":[{"given":"Sumaira","family":"Qayoom","sequence":"first","affiliation":[{"name":"Department of Pathology, King George\u2019s Medical University, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9511-6844","authenticated-orcid":false,"given":"Deep","family":"Chakrabarti","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy, King George\u2019s Medical University, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatima","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Pathology, King George\u2019s Medical University, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhu Mati","family":"Goel","sequence":"additional","affiliation":[{"name":"Department of Pathology, King George\u2019s Medical University, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2019,9,30]]},"reference":[{"key":"2025082722564446000_12.9.e230185.1","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.5858\/arpa.2011-0267-RS","article-title":"Small cell carcinoma of the urinary bladder: a rare, aggressive neuroendocrine malignancy","volume":"136","author":"Zhao","year":"2012","journal-title":"Arch Pathol Lab Med"},{"key":"2025082722564446000_12.9.e230185.2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"2025082722564446000_12.9.e230185.3","unstructured":"World Health Organization. Global Health Observatory. Geneva: World Health Organization, 2018. who.int\/gho\/database\/en\/"},{"key":"2025082722564446000_12.9.e230185.4","first-page":"e197","article-title":"Neuroendocrine tumor of the bladder","volume":"12","author":"Sehgal","year":"2010","journal-title":"Rev Urol"},{"key":"2025082722564446000_12.9.e230185.5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2009.08451.x"},{"key":"2025082722564446000_12.9.e230185.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.clgc.2012.11.002"},{"key":"2025082722564446000_12.9.e230185.7","doi-asserted-by":"crossref","first-page":"5325","DOI":"10.1002\/cncr.26197","article-title":"A Surveillance, Epidemiology, and End Results analysis of small cell carcinoma of the bladder: epidemiology, prognostic variables, and treatment trends","volume":"117","author":"Koay","year":"2011","journal-title":"Cancer"},{"key":"2025082722564446000_12.9.e230185.8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2008.08241.x"},{"key":"2025082722564446000_12.9.e230185.9","doi-asserted-by":"crossref","first-page":"326","DOI":"10.4103\/ijmpo.ijmpo_30_17","article-title":"Small cell carcinoma of urinary bladder: Analysis from a tertiary cancer care center of India","volume":"39","author":"Ram","year":"2018","journal-title":"Indian Journal of Medical and Paediatric Oncology"},{"key":"2025082722564446000_12.9.e230185.10","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1159\/000452945","article-title":"Transdifferentiation of Small Cell Carcinoma of the Urinary Bladder from Urothelial Carcinoma after Transurethral Resection of a Bladder Tumor, Intravesical Bacillus Calmette-Guerin Instillation, and Chemotherapy: A Case Report","volume":"9","author":"Morozumi","year":"2016","journal-title":"Case Rep Oncol"},{"key":"2025082722564446000_12.9.e230185.11","first-page":"697","article-title":"Small cell carcinoma occurring after treatment for urothelial cell carcinoma of the urinary bladder: a case report","volume":"72","author":"Goto","year":"2010","journal-title":"Nishinihon J Urol"},{"key":"2025082722564446000_12.9.e230185.12","first-page":"135","volume-title":"World Health Organization Classification of Tumours","volume":"vol 6","author":"Eble","year":"2004"},{"key":"2025082722564446000_12.9.e230185.13","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-004-1041-1"},{"key":"2025082722564446000_12.9.e230185.14","doi-asserted-by":"publisher","DOI":"10.1177\/1066896909359914"},{"key":"2025082722564446000_12.9.e230185.15","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2005.04.007"},{"key":"2025082722564446000_12.9.e230185.16","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.1999.00715.x"},{"key":"2025082722564446000_12.9.e230185.17","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.eururo.2012.04.020","article-title":"Neoadjuvant chemotherapy in small cell urothelial cancer improves pathologic downstaging and long-term outcomes: results from a retrospective study at the MD Anderson Cancer Center","volume":"64","author":"Lynch","year":"2013","journal-title":"Eur Urol"},{"key":"2025082722564446000_12.9.e230185.18","doi-asserted-by":"crossref","first-page":"44","DOI":"10.5489\/cuaj.220","article-title":"Management of small cell carcinoma of the bladder: Consensus guidelines from the Canadian Association of Genitourinary Medical Oncologists (CAGMO)","volume":"7","author":"Moretto","year":"2013","journal-title":"Can Urol Assoc J"},{"key":"2025082722564446000_12.9.e230185.19","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1097\/COC.0000000000000027","article-title":"Treatment of Small Cell Carcinoma of the Bladder With Chemotherapy and Radiation after Transurethral Resection of a Bladder Tumor","volume":"39","author":"Bryant","year":"2016","journal-title":"Am J Clin Oncol"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2019-230185","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T05:56:55Z","timestamp":1756360615000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2019-230185"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":19,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2019,9,30]]},"published-print":{"date-parts":[[2019,9]]}},"alternative-id":["10.1136\/bcr-2019-230185"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2019-230185","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9]]}}}