{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T17:04:11Z","timestamp":1784307851209,"version":"3.55.0"},"reference-count":9,"publisher":"BMJ","issue":"7","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2019,6,26]]},"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:p>Non-typhoidal <jats:italic>Salmonella spp.<\/jats:italic>are Gram-negative bacilli, which typically cause a clinical picture of gastroenteritis and, less commonly, patients may become a chronic carrier of the pathogen within their gallbladder. We describe a rare clinical presentation of a non-typhoidal <jats:italic>Salmonella spp.<\/jats:italic> infection as acute calculus cholecystitis in an adult patient. <jats:italic>Salmonella enterica<\/jats:italic> subsp. Salamae (ST P4271) was grown from cholecystostomy fluid, and the patient subsequently underwent a laparoscopic cholecystectomy that demonstrated a necrotic gallbladder fundus. We advise that microbiological sampling of bile is essential, especially in the context of foreign travel, to detect unusual pathogens as in this case or common pathogens that may have unusual antimicrobial resistance. Given the necrotic gallbladder as in this case, we also advise that early cholecystectomy should be strongly considered in these patients.<\/jats:p>","DOI":"10.1136\/bcr-2019-230186","type":"journal-article","created":{"date-parts":[[2019,7,20]],"date-time":"2019-07-20T06:25:15Z","timestamp":1563603915000},"page":"e230186","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Non-typhoidal salmonellosis presenting as acute calculus cholecystitis"],"prefix":"10.1136","volume":"12","author":[{"given":"Fatema","family":"Juma","sequence":"first","affiliation":[{"name":"London North West University Healthcare NHS Trust , Harrow, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua J","family":"Cave","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Chelsea and Westminster NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hector","family":"Gonzales","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Chelsea and Westminster NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7095-7922","authenticated-orcid":false,"given":"Luke Stephen Prockter","family":"Moore","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Imperial College Healthcare NHS Trust, London, UK"},{"name":"HPRU in Healthcare Associated Infection and Antimicrobial Resistance, Imperial College London, London, UK"},{"name":"Clinical Infection Department, Chelsea & Westminster NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2019,7,19]]},"reference":[{"key":"2025082708321830000_12.7.e230186.1","doi-asserted-by":"publisher","DOI":"10.1086\/318457"},{"key":"2025082708321830000_12.7.e230186.2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra020201"},{"key":"2025082708321830000_12.7.e230186.3","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.3390\/ijms18091887","article-title":"Biofilm producing salmonella typhi: chronic colonization and development of gallbladder cancer","volume":"18","author":"Di Domenico","year":"2017","journal-title":"Int J Mol Sci"},{"key":"2025082708321830000_12.7.e230186.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2014.06.007"},{"key":"2025082708321830000_12.7.e230186.5","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.tmaid.2009.05.006","article-title":"Acute acalculous cholecystitis complicating typhoid fever in an adult patient: a case report and review of the literature","volume":"7","author":"Khan","year":"2009","journal-title":"Travel Med Infect Dis"},{"key":"2025082708321830000_12.7.e230186.6","first-page":"301","article-title":"Unusual manifestations of salmonellosis--a surgical problem","volume":"87","author":"Lalitha","year":"1994","journal-title":"Q J Med"},{"key":"2025082708321830000_12.7.e230186.7","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1055\/s-2008-1066246","article-title":"Cholecystolithiasis and infection of the biliary tract with Salmonella Virchow--a very rare case in early childhood","volume":"5","author":"Beiler","year":"1995","journal-title":"Eur J Pediatr Surg"},{"key":"2025082708321830000_12.7.e230186.8","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/93.6.389"},{"key":"2025082708321830000_12.7.e230186.9","unstructured":"Gallstone disease. The National institue for health and care excellence clinical guideline. 2014 https:\/\/www.nice.org.uk\/guidance\/cg188 (Accessed 27 Sep 2018)."}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2019-230186","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T15:32:25Z","timestamp":1756308745000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2019-230186"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":9,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2019,7,19]]},"published-print":{"date-parts":[[2019,7]]}},"alternative-id":["10.1136\/bcr-2019-230186"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2019-230186","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7]]}}}