{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T13:05:10Z","timestamp":1793451910185,"version":"4.5.0"},"reference-count":21,"publisher":"BMJ","issue":"9","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2019,8,20]]},"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:p>A 26-year-old Caucasian man with no medical history, except years of oral and intravenous drug abuse, presented with fatigue, shortness of breath, epistaxis and uncontrolled hypertension. He was pale with skin ecchymosis over his thighs and was anaemic, with severe renal failure and metabolic acidosis. Following initial clinical stabilisation of the patient, a renal biopsy was obtained, which showed vascular and glomerular changes consistent with thrombotic microangiopathic injury and advanced glomerulosclerosis. He was treated with antihypertensives and required haemodialysis. He admitted using \u2018crystal meth\u2019 regularly for many years, which is likely responsible for his renal failure. We present the case to illustrate methamphetamine-induced renal disease leading to end-stage renal disease and to bring awareness among practising clinicians, ancillary healthcare workers and public health professionals of this often undervalued cause of renal failure, which can be prevented.<\/jats:p>","DOI":"10.1136\/bcr-2019-230288","type":"journal-article","created":{"date-parts":[[2019,9,19]],"date-time":"2019-09-19T16:49:07Z","timestamp":1568911747000},"page":"e230288","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":22,"title":["Methamphetamine (\n                    <i>N<\/i>\n                    -methylamphetamine)-induced renal disease: underevaluated cause of end-stage renal disease (ESRD)"],"prefix":"10.1136","volume":"12","author":[{"given":"Krishna M","family":"Baradhi","sequence":"first","affiliation":[{"name":"Nephrology, University of Oklahoma School of Community Medicine, Tulsa, Oklahoma, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samata","family":"Pathireddy","sequence":"additional","affiliation":[{"name":"Internal Medicine, Deaconess Health System, Evansville, Indiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhasish","family":"Bose","sequence":"additional","affiliation":[{"name":"Nephrology, Lynchburg Nephrology, Lynchburg, Virginia, USA"},{"name":"Medicine, University of Virginia, Charlottesville, Virginia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narothama Reddy","family":"Aeddula","sequence":"additional","affiliation":[{"name":"Medicine, Deaconess Health System, Evansville, Indiana, USA"},{"name":"Medicine, Indiana University School of Medicine, Evansville, Indiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2019,9,19]]},"reference":[{"key":"2025082708442232000_12.9.e230288.1","unstructured":"Results from the 2013 National Survey on Drug Use and Health: Summary of National Findings. 2013. https:\/\/www.samhsa.gov\/data\/sites\/default\/files\/NSDUHresultsPDFWHTML2013\/Web\/NSDUHresults2013.htm (cited 10 Mar 2019)."},{"key":"2025082708442232000_12.9.e230288.2","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1016\/j.ekir.2018.07.003","article-title":"N-methylamphetamine (\u201cCrystal Meth\u201d)\u2212Associated Acute Renal Cortical Necrosis","volume":"3","author":"Gupta","year":"2018","journal-title":"Kidney Int Rep"},{"key":"2025082708442232000_12.9.e230288.3","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/S0022-3565(25)10706-4","article-title":"Pharmacokinetic and pharmacodynamic analysis of the actions of D-amphetamine and D-methamphetamine on the dopamine terminal","volume":"274","author":"Melega","year":"1995","journal-title":"J Pharmacol Exp Ther"},{"key":"2025082708442232000_12.9.e230288.4","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s00213-007-0923-8","article-title":"A comparison of amphetamine- and methamphetamine-induced locomotor activity in rats: evidence for qualitative differences in behavior","volume":"195","author":"Hall","year":"2008","journal-title":"Psychopharmacology"},{"key":"2025082708442232000_12.9.e230288.5","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.305.6844.29"},{"key":"2025082708442232000_12.9.e230288.6","doi-asserted-by":"crossref","first-page":"199","DOI":"10.7196\/SAMJ.8731","article-title":"Hypertension, end-stage renal disease and mesangiocapillary glomerulonephritis in methamphetamine users","volume":"105","author":"Jones","year":"2015","journal-title":"S Afr Med J"},{"key":"2025082708442232000_12.9.e230288.7","first-page":"301","article-title":"The need for speed: an update on methamphetamine addiction","volume":"31","author":"Barr","year":"2006","journal-title":"J Psychiatry Neurosci"},{"key":"2025082708442232000_12.9.e230288.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2017.02.017"},{"key":"2025082708442232000_12.9.e230288.9","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1097\/00004836-199112000-00015","article-title":"Methamphetamine-induced ischemic colitis","volume":"13","author":"Johnson","year":"1991","journal-title":"J Clin Gastroenterol"},{"key":"2025082708442232000_12.9.e230288.10","first-page":"169","article-title":"Amaurosis fugax and retinal vasculitis associated with methamphetamine inhalation","volume":"5","author":"Shaw","year":"1985","journal-title":"J Clin Neuroophthalmol"},{"key":"2025082708442232000_12.9.e230288.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2005.04.003"},{"key":"2025082708442232000_12.9.e230288.12","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.071675"},{"key":"2025082708442232000_12.9.e230288.13","doi-asserted-by":"publisher","DOI":"10.1177\/0885066609340519"},{"key":"2025082708442232000_12.9.e230288.14","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvq043"},{"key":"2025082708442232000_12.9.e230288.15","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1002\/jnr.23697","article-title":"Methamphetamine induces the release of endothelin","volume":"94","author":"Seo","year":"2016","journal-title":"J Neurosci Res"},{"key":"2025082708442232000_12.9.e230288.16","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.legalmed.2005.07.003","article-title":"Changes in renal function and oxidative damage in methamphetamine-treated rat","volume":"8","author":"Tokunaga","year":"2006","journal-title":"Leg Med"},{"key":"2025082708442232000_12.9.e230288.17","doi-asserted-by":"publisher","DOI":"10.1177\/0960327112438287"},{"key":"2025082708442232000_12.9.e230288.18","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-73-1-81"},{"key":"2025082708442232000_12.9.e230288.19","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-6757(99)90159-6"},{"key":"2025082708442232000_12.9.e230288.20","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.drugalcdep.2019.03.019","article-title":"Multi-drug cocktails: Impurities in commonly used illicit drugs seized by police in Queensland, Australia","volume":"201","author":"Peck","year":"2019","journal-title":"Drug Alcohol Depend"},{"key":"2025082708442232000_12.9.e230288.21","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1002\/jssc.201601313","article-title":"Chemometrics-assisted chromatographic fingerprinting: An illicit methamphetamine case study","volume":"40","author":"Shekari","year":"2017","journal-title":"J Sep Sci"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2019-230288","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T15:44:28Z","timestamp":1756309468000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2019-230288"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":21,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2019,9,19]]},"published-print":{"date-parts":[[2019,9]]}},"alternative-id":["10.1136\/bcr-2019-230288"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2019-230288","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9]]}}}