{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:02:19Z","timestamp":1756425739798,"version":"3.44.0"},"reference-count":19,"publisher":"BMJ","issue":"7","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2019,6,20]]},"published-print":{"date-parts":[[2019,7,10]]},"abstract":"<jats:p>Primary gastric squamous cell carcinoma (SCC) is rare, and the simultaneous <jats:italic>Helicobacter pylori<\/jats:italic> infection has not been reported in the literature. Here, we presented a patient with concurrent <jats:italic>H. pylori<\/jats:italic> gastritis and primary gastric SCC. A 54-year-old Hispanic man presented with diarrhoea, chills, night sweats and weight loss of 16 lbs for the previous 6 weeks. Abdominal CT revealed large exophytic mass from the stomach infiltrating multiple organs. Biopsy was performed and histology showed squamoid features. Immunohistochemistry stain was positive for p40, CK5\/6, CK7 and Helicobacter type organisms. Patient was diagnosed with primary gastric SCC and has been receiving chemotherapy. We also reviewed the diagnosis, prognosis and treatment of primary gastric SCC.<\/jats:p>","DOI":"10.1136\/bcr-2019-230310","type":"journal-article","created":{"date-parts":[[2019,7,11]],"date-time":"2019-07-11T05:45:31Z","timestamp":1562823931000},"page":"e230310","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Exophytic primary gastric squamous cell carcinoma and <i>H. pylori<\/i> gastritis"],"prefix":"10.1136","volume":"12","author":[{"given":"Kehua","family":"Zhou","sequence":"first","affiliation":[{"name":"Catholic Health Internal Medicine Training Program, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aniqa","family":"Faraz","sequence":"additional","affiliation":[{"name":"Catholic Health Internal Medicine Training Program, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minoti","family":"Magotra","sequence":"additional","affiliation":[{"name":"Mercy Hospital of Buffalo, Buffalo, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Tahir","sequence":"additional","affiliation":[{"name":"Catholic Health Internal Medicine Training Program, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,7,10]]},"reference":[{"key":"2025082723184612000_12.7.e230310.1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"2025082723184612000_12.7.e230310.2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i16.4483"},{"key":"2025082723184612000_12.7.e230310.3","unstructured":"Key Statistics About Stomach Cancer [Internet]. https:\/\/www.cancer.org\/cancer\/stomach-cancer\/about\/key-statistics.html"},{"key":"2025082723184612000_12.7.e230310.4","doi-asserted-by":"crossref","first-page":"2122","DOI":"10.3892\/ol.2014.2492","article-title":"Primary squamous cell carcinoma of the stomach: A case report","volume":"8","author":"Hwang","year":"2014","journal-title":"Oncol Lett"},{"key":"2025082723184612000_12.7.e230310.5","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.01.028"},{"key":"2025082723184612000_12.7.e230310.6","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2012.1701"},{"key":"2025082723184612000_12.7.e230310.7","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.jcmgh.2016.12.001","article-title":"The Clinical Evidence Linking Helicobacter pylori to Gastric Cancer","volume":"3","author":"Moss","year":"2017","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"2025082723184612000_12.7.e230310.8","doi-asserted-by":"publisher","DOI":"10.1136\/gut.49.3.347"},{"key":"2025082723184612000_12.7.e230310.9","first-page":"1","article-title":"Clinicopathological Characteristics, Treatment, and Prognosis of 21 Patients with Primary Gastric Squamous Cell Carcinoma","volume":"2016","author":"Chen","year":"2016","journal-title":"Gastroenterol Res Pract"},{"key":"2025082723184612000_12.7.e230310.10","doi-asserted-by":"crossref","first-page":"447","DOI":"10.2214\/ajr.101.2.447","article-title":"Squamous neoplasms of the stomach","volume":"101","author":"PARKS","year":"1967","journal-title":"Am J Roengen"},{"key":"2025082723184612000_12.7.e230310.11","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-011-0041-5"},{"key":"2025082723184612000_12.7.e230310.12","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1002\/1097-0142(196502)18:2<181::AID-CNCR2820180209>3.0.CO;2-3","article-title":"Squamous cell carcinoma and adenoacanthoma of the stomach. 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