{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T19:10:01Z","timestamp":1756321801739,"version":"3.44.0"},"reference-count":13,"publisher":"BMJ","issue":"8","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2019,6,17]]},"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:p>Marchiafava-Bignami disease (MBD) is a rare complication of chronic alcoholism; however, MBD in a non-alcoholic diabetic patient has rarely been reported. The aetiology or pathophysiology of MBD is still unknown. A 50-year-old man with a history of untreated diabetes mellitus underwent on-pump beating coronary artery bypass graft surgery (CABG) surgery for three-vessel and left main coronary disease. 3 days after the surgery, he developed a fever over 40\u00b0C and entered a coma state. MRI revealed multiple lesions, including in the corpus callosum, globus pallidus, brain stem and upper cervical spinal cord, which suggested MBD. The patient did not respond to thiamine therapy, but partly responded to steroid therapy. He ultimately died of respiratory failure. The autopsy revealed MBD and haemophagocytic lymphohistiocytosis. It is rare, but systemic inflammatory response syndrome induced by on-pump beating CABG could develop these complication.<\/jats:p>","DOI":"10.1136\/bcr-2019-230368","type":"journal-article","created":{"date-parts":[[2019,8,26]],"date-time":"2019-08-26T13:55:27Z","timestamp":1566827727000},"page":"e230368","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Marchiafava-Bignami disease with haemophagocytic lymphohistiocytosis as a postoperative complication of cardiac surgery"],"prefix":"10.1136","volume":"12","author":[{"given":"Kentarou","family":"Takei","sequence":"first","affiliation":[{"name":"Neurology, Osaki Citizen Hospital, Osaki, Miyagi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naotaka","family":"Motoyoshi","sequence":"additional","affiliation":[{"name":"Cardiovascular Surgery, Osaki Citizen Hospital, Osaki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Pathology, Osaki Citizen Hospital, Osaki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuyuki","family":"Kitamoto","sequence":"additional","affiliation":[{"name":"Neurological Science, Tohoku University School of Medicine, Sendai, Miyagi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,8,26]]},"reference":[{"key":"2025082711343160000_12.8.e230368.1","first-page":"544","article-title":"Sopra un alterazione del corpo calloso osservata in soggetti alcoolisti","volume":"8","author":"Marchiafava","year":"1903","journal-title":"Rivistadi Patologia Nervosa e Mentale"},{"key":"2025082711343160000_12.8.e230368.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2007.02.011"},{"key":"2025082711343160000_12.8.e230368.3","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.jocn.2011.07.040","article-title":"A patient with Marchiafava-Bignami disease as a complication of diabetes mellitus treated effectively with corticosteroid","volume":"19","author":"Suzuki","year":"2012","journal-title":"J Clin Neurosci"},{"key":"2025082711343160000_12.8.e230368.4","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.59.9.1422"},{"key":"2025082711343160000_12.8.e230368.5","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000009198","article-title":"Hemophagocytic lymphohistiocytosis complicated by multiorgan failure: A case report","volume":"96","author":"Lovisari","year":"2017","journal-title":"Medicine"},{"key":"2025082711343160000_12.8.e230368.6","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-007-0320-8"},{"key":"2025082711343160000_12.8.e230368.7","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2013-305979"},{"key":"2025082711343160000_12.8.e230368.8","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.0b013e3182553ced","article-title":"Unusual MRI findings in a case of Marchiafava Bignami disease","volume":"78","author":"Bellido","year":"2012","journal-title":"Neurology"},{"key":"2025082711343160000_12.8.e230368.9","doi-asserted-by":"crossref","DOI":"10.1186\/s13063-016-1265-9","article-title":"RECCAS - REmoval of Cytokines during CArdiac Surgery: study protocol for a randomised controlled trial","volume":"17","author":"Baumann","year":"2016","journal-title":"Trials"},{"key":"2025082711343160000_12.8.e230368.10","doi-asserted-by":"publisher","DOI":"10.1309\/AJCP4ZDKJ4ICOUAT"},{"key":"2025082711343160000_12.8.e230368.11","doi-asserted-by":"publisher","DOI":"10.1017\/S1740925X05000608"},{"key":"2025082711343160000_12.8.e230368.12","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2003.01984.x"},{"key":"2025082711343160000_12.8.e230368.13","doi-asserted-by":"publisher","DOI":"10.1148\/rg.2017160085"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2019-230368","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T18:34:39Z","timestamp":1756319679000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2019-230368"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":13,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2019,8,26]]},"published-print":{"date-parts":[[2019,8]]}},"alternative-id":["10.1136\/bcr-2019-230368"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2019-230368","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2019,8]]}}}