{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T10:11:09Z","timestamp":1789726269864,"version":"4.0.1"},"reference-count":12,"publisher":"BMJ","issue":"6","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2019,6,17]]},"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:p>Direct oral anticoagulants (DOACs)\u2014dabigatran, rivaroxaban, apixaban and edoxaban\u2014are changing the landscape of clinical practice for patients requiring short and long-term anticoagulation. We report a patient with no history of kidney disease developing acute interstitial nephritis (AIN) after starting a DOAC, apixaban. To date, this is the first biopsy proven case of apixaban-induced AIN.<\/jats:p>","DOI":"10.1136\/bcr-2019-230371","type":"journal-article","created":{"date-parts":[[2019,6,29]],"date-time":"2019-06-29T12:55:14Z","timestamp":1561812914000},"page":"e230371","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":12,"title":["Direct oral anticoagulant and AKI: apixaban-induced acute interstitial nephritis"],"prefix":"10.1136","volume":"12","author":[{"given":"Christina","family":"DiMaria","sequence":"first","affiliation":[{"name":"Internal Medicine, Albert Einstein Medical Center, Philadelphia, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wael","family":"Hanna","sequence":"additional","affiliation":[{"name":"Hospital Medicine, Lehigh Valley Hospital\u2014Cedar Crest, Allentown, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Murone","sequence":"additional","affiliation":[{"name":"Medicine, Philadelphia College of Medicine, Philadelphia, Pennsylvannia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Reichart","sequence":"additional","affiliation":[{"name":"Hospital Medicine, Lehigh Valley Hospital\u2014Cedar Crest, Allentown, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2019,6,29]]},"reference":[{"key":"2025082804453213000_12.6.e230371.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2015.05.044"},{"key":"2025082804453213000_12.6.e230371.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2014.05.013"},{"key":"2025082804453213000_12.6.e230371.3","doi-asserted-by":"crossref","first-page":"791","DOI":"10.14740\/jocmr3569w","article-title":"Dabigatran-induced acute interstitial nephritis: an important complication of newer oral anticoagulation agents","volume":"10","author":"Patel","year":"2018","journal-title":"J Clin Med Res"},{"key":"2025082804453213000_12.6.e230371.4","doi-asserted-by":"crossref","first-page":"bcr-2017-221641","DOI":"10.1136\/bcr-2017-221641","article-title":"Novel oral anticoagulant and kidney injury: apixaban-related acute interstitial nephritis","volume":"2017","author":"Abdulhadi","year":"2017","journal-title":"BMJ Case Rep"},{"key":"2025082804453213000_12.6.e230371.5","doi-asserted-by":"crossref","first-page":"B24","DOI":"10.1053\/j.ajkd.2013.02.039","article-title":"A Cautionary Tale: Dabigatran Toxicity Associated With Allergic Interstitial Nephritis","volume":"61","year":"2013","journal-title":"American Journal of Kidney Diseases"},{"key":"2025082804453213000_12.6.e230371.6","doi-asserted-by":"crossref","first-page":"967","DOI":"10.2147\/TCRM.S84210","article-title":"New oral anticoagulants: their advantages and disadvantages compared with vitamin K antagonists in the prevention and treatment of patients with thromboembolic events","volume":"11","author":"Mekaj","year":"2015","journal-title":"Ther Clin Risk Manag"},{"key":"2025082804453213000_12.6.e230371.7","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2018-227756","article-title":"Rivaroxaban-related acute kidney injury in a patient with IgA vasculitis","volume":"12","author":"Fujino","year":"2019","journal-title":"BMJ Case Rep"},{"key":"2025082804453213000_12.6.e230371.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2015.09.046"},{"key":"2025082804453213000_12.6.e230371.9","doi-asserted-by":"crossref","unstructured":"Brodsky SV , Mhaskar NS , Thiruveedi S , et al . Acute kidney injury aggravated by treatment initiation with apixaban: Another twist of anticoagulant-related nephropathy. Kidney Res Clin Pract 2017;36.doi:10.23876\/j.krcp.2017.36.4.387","DOI":"10.23876\/j.krcp.2017.36.4.387"},{"key":"2025082804453213000_12.6.e230371.10","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.krcp.2014.11.001","article-title":"Anticoagulants and acute kidney injury: clinical and pathology considerations","volume":"33","author":"Brodsky","year":"2014","journal-title":"Kidney Res Clin Pract"},{"key":"2025082804453213000_12.6.e230371.11","first-page":"179","article-title":"The outcome of acute interstitial nephritis: risk factors for the transition from acute to chronic interstitial nephritis","volume":"54","author":"Schwarz","year":"2000","journal-title":"Clin Nephrol"},{"key":"2025082804453213000_12.6.e230371.12","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.63.6s.2.x"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2019-230371","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T11:45:39Z","timestamp":1756381539000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2019-230371"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":12,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2019,6,29]]},"published-print":{"date-parts":[[2019,6]]}},"alternative-id":["10.1136\/bcr-2019-230371"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2019-230371","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6]]}}}