{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T10:51:41Z","timestamp":1761648701678,"version":"3.44.0"},"reference-count":10,"publisher":"BMJ","issue":"9","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2019,8,13]]},"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:p>Oculopharyngeal muscular dystrophy (OPMD) is a relatively rare, adult-onset disorder characterised by proximal limb weakness, progressive eyelid drooping and swallowing difficulties. Preliminary research suggests there could be a link between OPMD and dementia; however, the current literature is relatively limited and inconsistent. This case study describes a 75-year-old female with OPMD, presenting to an older adults community mental health team with memory problems and word finding difficulties. A neuropsychological assessment was carried out. The results of her assessment were difficult to interpret; she demonstrated impairments in most cognitive domains tested and her presentation did not appear to reflect any typical dementia profile. It was thought she was most likely presenting with a dementia; however, the exact aetiology remains unclear. The dementia could be a result of OPMD, vascular changes or both. This report emphasises the need for further research into the possible causal link between OPMD and dementia\/cognitive decline.<\/jats:p>","DOI":"10.1136\/bcr-2019-230521","type":"journal-article","created":{"date-parts":[[2019,9,19]],"date-time":"2019-09-19T16:45:16Z","timestamp":1568911516000},"page":"e230521","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Oculopharyngeal muscular dystrophy (OPMD) and dementia in a 75-year-old female"],"prefix":"10.1136","volume":"12","author":[{"given":"Mhairi Kathryn","family":"Nisbet","sequence":"first","affiliation":[{"name":"Department of Learning Disability, NHS Greater Glasgow and Clyde, Glasgow, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise","family":"Marshall","sequence":"additional","affiliation":[{"name":"Department of Older Adult Psychology, NHS Greater Glasgow and Clyde, Glasgow, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,9,19]]},"reference":[{"key":"2025082723395248000_12.9.e230521.1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1040826"},{"key":"2025082723395248000_12.9.e230521.2","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1017\/S0317167100002365","article-title":"Progress in understanding the pathogenesis of oculopharyngeal muscular dystrophy","volume":"30","author":"Fan","year":"2003","journal-title":"Can J Neurol Sci"},{"key":"2025082723395248000_12.9.e230521.3","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(199907)46:1<115::AID-ANA17>3.0.CO;2-O"},{"key":"2025082723395248000_12.9.e230521.4","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1212\/WNL.0b013e3181b388a3","article-title":"Cognitive impairment and reduced life span of oculopharyngeal muscular dystrophy homozygotes","volume":"73","author":"Blumen","year":"2009","journal-title":"Neurology"},{"key":"2025082723395248000_12.9.e230521.5","first-page":"55","article-title":"Profiling Brain Functioning in Muscular Dystrophies (MD): Upgrading Knowledge from on-Going Research","volume":"37","author":"Baldanzi","year":"2018","journal-title":"Acta Myologica"},{"key":"2025082723395248000_12.9.e230521.6","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.eurger.2016.11.005","article-title":"Oculopharyngeal muscular dystrophy with frontotemporal dementia","volume":"8","author":"van der Sluijs","year":"2017","journal-title":"Eur Geriatr Med"},{"key":"2025082723395248000_12.9.e230521.7","doi-asserted-by":"crossref","first-page":"P682","DOI":"10.1016\/j.jalz.2014.05.1238","article-title":"Dementia syndrome in oculopharyngeal muscular dystrophy: A trinucleotide expansion disorder commonly presenting with muscle weakness","volume":"10","author":"Frederick","year":"2014","journal-title":"Alzheimer\u2019s & Dementia"},{"key":"2025082723395248000_12.9.e230521.8","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-011-6255-y"},{"issue":"15 Supplement","key":"2025082723395248000_12.9.e230521.9","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.90.15_supplement.S31.001","article-title":"The natural history of impairments and disabilities in Oculopharyngeal Muscular Dystrophy: a large retrospective study","volume":"90","author":"Brisson","year":"2018","journal-title":"Neurology"},{"key":"2025082723395248000_12.9.e230521.10","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.2169\/internalmedicine.50.5577","article-title":"Oculopharyngeal muscular dystrophy associated with dementia","volume":"50","author":"Mizoi","year":"2011","journal-title":"Intern Med"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2019-230521","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T06:40:03Z","timestamp":1756363203000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2019-230521"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":10,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2019,9,19]]},"published-print":{"date-parts":[[2019,9]]}},"alternative-id":["10.1136\/bcr-2019-230521"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2019-230521","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2019,9]]}}}