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Pleural fluid analysis revealed an exudative effusion; cytology showed mature plasma cells and plasmablasts. Serum electrophoresis revealed an M band in the gamma region. Biopsy of the supraclavicular mass revealed plasma cells which were CD 138+ with Kappa light chain restriction. She was initiated on chemotherapy and is currently doing well. Myelomatous pleural effusion is a rare presentation of multiple myeloma.<\/jats:p>","DOI":"10.1136\/bcr-2019-230560","type":"journal-article","created":{"date-parts":[[2019,9,13]],"date-time":"2019-09-13T04:59:05Z","timestamp":1568350745000},"page":"e230560","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Myelomatous pleural effusion and extensive extraskeletal soft tissue involvement: a rare presentation of clonal plasma cell disorders"],"prefix":"10.1136","volume":"12","author":[{"given":"Vijay","family":"Alexander","sequence":"first","affiliation":[{"name":"Department of Medicine, Unit-3, Christian Medical College and Hospital Vellore, Vellore, Tamil Nadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6644-657X","authenticated-orcid":false,"given":"Aditya John","family":"Binu","sequence":"additional","affiliation":[{"name":"Department of Medicine, Unit-3, Christian Medical College and Hospital Vellore, Vellore, Tamil Nadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sowmya","family":"Sathyendra","sequence":"additional","affiliation":[{"name":"Department of Medicine, Unit-3, Christian Medical College and Hospital Vellore, Vellore, Tamil Nadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,9,12]]},"reference":[{"key":"2025082703174539000_12.9.e230560.1","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1016\/0277-5379(91)90020-E","article-title":"Changing clinical presentation of multiple myeloma","volume":"27","author":"Riccardi","year":"1991","journal-title":"Eur J Cancer Oxf Engl"},{"key":"2025082703174539000_12.9.e230560.2","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.rce.2017.11.001","article-title":"Characteristics of patients with myelomatous pleural effusion. 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