{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T16:10:05Z","timestamp":1756311005723,"version":"3.44.0"},"reference-count":16,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2020,1,8]]},"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>Muscular dystrophies are a heterogeneous group of disorders that commonly involve cardiac and skeletal muscle. Comprehensive guidelines for the management of cardiac failure and arrhythmias are available. However, the studies from which their recommendations are derived did not include any patients with muscular dystrophy. Some medications (eg, betablockers) may have significant side effects in this cohort. In some situations the use of agents with unique mechanisms of action such as ivabradine (a \u2018funny\u2019 channel inhibitor) may be more appropriate. Use of ivabradine has not previously been reported in limb girdle muscular dystrophy (LGMD). We describe the course of a patient with LGMD type 2I, cardiomyopathy and inappropriate sinus tachycardia treated with ivabradine. As advances in respiratory support have improved the outcomes of patients with muscular dystrophy; the prognostic significance of cardiac disease has increased. Ivabradine is tolerated and may reduce symptoms, morbidity and mortality in this cohort.<\/jats:p>","DOI":"10.1136\/bcr-2019-230647","type":"journal-article","created":{"date-parts":[[2020,1,22]],"date-time":"2020-01-22T05:14:23Z","timestamp":1579670063000},"page":"e230647","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["The use of ivabradine in a patient with inappropriate sinus tachycardia and cardiomyopathy due to limb girdle muscular dystrophy type 2I"],"prefix":"10.1136","volume":"13","author":[{"given":"Rajkumar","family":"Rajendram","sequence":"first","affiliation":[{"name":"Department of Anaesthesia and Intensive Care, Stoke Mandeville Hospital, Aylesbury, Buckinghamshire, UK"},{"name":"College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fahad","family":"AlDhahri","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, King Abdulaziz Medical City, Riyadh, Al Riyadh Province, Saudi Arabia"},{"name":"College of Pharmacy, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naveed","family":"Mahmood","sequence":"additional","affiliation":[{"name":"College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia"},{"name":"Department of Medicine, King Abdulaziz Medical City, Riyadh, Al Riyadh Province, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mubashar","family":"Kharal","sequence":"additional","affiliation":[{"name":"College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia"},{"name":"Department of Medicine, King Abdulaziz Medical City, Riyadh, Al Riyadh Province, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2020,1,21]]},"reference":[{"key":"2025082708552376000_13.1.e230647.1","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1093\/eurheartj\/ehw128","article-title":"2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC)Developed with the special contribution of the Heart Failure Association (HFA) of the ESC","volume":"37","author":"Ponikowski","year":"2016","journal-title":"Eur J Heart Fail"},{"key":"2025082708552376000_13.1.e230647.2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000311"},{"key":"2025082708552376000_13.1.e230647.3","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1007\/s00059-012-3643-8","article-title":"Beneficial effect of ivabradine in dilated cardiomyopathy from Becker muscular dystrophy","volume":"37","author":"Finsterer","year":"2012","journal-title":"Herz"},{"key":"2025082708552376000_13.1.e230647.4","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.ijcard.2016.08.135","article-title":"Effect of ivabradine in dilated cardiomyopathy from Duchenne muscular dystrophy: a chance for slowing progression of heart failure?","volume":"223","author":"De Benedittis","year":"2016","journal-title":"Int J Cardiol"},{"key":"2025082708552376000_13.1.e230647.5","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e32830efdc2"},{"key":"2025082708552376000_13.1.e230647.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2009.12.013"},{"key":"2025082708552376000_13.1.e230647.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.02.017"},{"key":"2025082708552376000_13.1.e230647.8","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.65.9.1196"},{"key":"2025082708552376000_13.1.e230647.9","doi-asserted-by":"crossref","DOI":"10.1136\/jmg.2003.013953","article-title":"FKRP (826C>A) frequently causes limb-girdle muscular dystrophy in German patients","volume":"41","author":"Walter","year":"2004","journal-title":"J Med Genet"},{"key":"2025082708552376000_13.1.e230647.10","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20283"},{"key":"2025082708552376000_13.1.e230647.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.08.038"},{"key":"2025082708552376000_13.1.e230647.12","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61170-8"},{"key":"2025082708552376000_13.1.e230647.13","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61198-1"},{"key":"2025082708552376000_13.1.e230647.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.06.031"},{"key":"2025082708552376000_13.1.e230647.15","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eus204"},{"key":"2025082708552376000_13.1.e230647.16","doi-asserted-by":"publisher","DOI":"10.1177\/1074248413478172"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2019-230647","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T15:55:30Z","timestamp":1756310130000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2019-230647"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":16,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,1,21]]},"published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1136\/bcr-2019-230647"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2019-230647","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2020,1]]}}}