{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T02:12:58Z","timestamp":1781921578144,"version":"3.54.5"},"reference-count":8,"publisher":"BMJ","issue":"11","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2019,10,17]]},"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:p>Nasopharyngeal carcinoma (NPC), an uncommon malignancy in Western Countries and Radiotherapy, remains an effective treatment. Its side effects are classified as either immediate or late; postradiation necrosis is as an important late side effect with a strong impact on the prognosis in patients with NPC. We report the case of 65-year-old Caucasian man presenting with a deep necrotic ulcer of the nasopharynx and osteoradionecrosis of the skull base that appeared 3\u2009months after radiotherapy for nasopharyngeal carcinoma. Conservative treatment was applied with surgical management of the ulcer. Clinical and radiological outcomes are presented. Radiotherapy remains a good treatment option with varying degrees of side effects, in particular, postradiation necrosis and ulcer. Multiple options of treatment have been described. However, the surgical management could be indicated in cases of deep ulcer with life-threatening prognosis.<\/jats:p>","DOI":"10.1136\/bcr-2019-230700","type":"journal-article","created":{"date-parts":[[2019,11,6]],"date-time":"2019-11-06T04:39:14Z","timestamp":1573015154000},"page":"e230700","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["Deep radiation-induced ulcer following nasopharyngeal carcinoma: surgical management"],"prefix":"10.1136","volume":"12","author":[{"given":"Bassel","family":"Hallak","sequence":"first","affiliation":[{"name":"Otorhinolaryngology, Hospital of Sion, Sion, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miranda","family":"Morrison","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology, Hospital of Sion, Sion, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Kohler","sequence":"additional","affiliation":[{"name":"Radiology, Hospital Sion, Sion, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salim","family":"Bouayed","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology, Hospital of Sion, Sion, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2019,11,5]]},"reference":[{"key":"2025082704045250000_12.11.e230700.1","doi-asserted-by":"publisher","DOI":"10.1016\/S1044579X02000858"},{"key":"2025082704045250000_12.11.e230700.2","doi-asserted-by":"publisher","DOI":"10.1259\/0007-1285-65-778-918"},{"key":"2025082704045250000_12.11.e230700.3","first-page":"729","article-title":"[Short-term efficacy of endoscopy-guided debridement on radiation-related nasopharyngeal necrosis in 20 nasopharyngeal carcinoma patients after radiotherapy]","volume":"27","author":"Hua","year":"2008","journal-title":"Ai Zheng"},{"key":"2025082704045250000_12.11.e230700.4","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21036"},{"key":"2025082704045250000_12.11.e230700.5","unstructured":"Ming YC , Hai QM , Rui S , et al . Clinical findings and imaging features of 67 nasopharyngeal carcinoma patients with postradiation nasopharyngeal necrosis."},{"key":"2025082704045250000_12.11.e230700.6","unstructured":"Fengqin Y , Zhimin YE , FangzhengW LW , et al . Clinical and imaging characteristics of 53 ulcers of post-radiation nasopharyngeal necrosis in patients with nasopharyngeal carcinoma."},{"key":"2025082704045250000_12.11.e230700.7","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199908000-00027"},{"key":"2025082704045250000_12.11.e230700.8","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000230435.71328.b9"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2019-230700","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T11:04:59Z","timestamp":1756292699000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2019-230700"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11]]},"references-count":8,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2019,11,5]]},"published-print":{"date-parts":[[2019,11]]}},"alternative-id":["10.1136\/bcr-2019-230700"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2019-230700","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11]]}}}