{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T06:34:03Z","timestamp":1772692443857,"version":"3.50.1"},"reference-count":8,"publisher":"BMJ","issue":"11","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2019,10,4]]},"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:p>Pazopanib is a vascular endothelial growth factor receptor tyrosine kinase inhibitor (VEGFR TKI) that inhibits the vascular endothelial growth factor receptor A pathway and has the potential to cause ischaemic bowel changes, including perforation. Here we report a case of a 51-year-old man with large, metastatic, retroperitoneal leiomyosarcoma that developed a tumour-bowel fistula after 4 weeks of pazopanib therapy. He presented to the emergency department with sepsis and 1-week history of worsening fever, chills, nausea and diarrhoea. Abdominal CT findings of mesenteric and portal vein gas, commonly found in mesenteric ischaemia and VEGFR modulator-induced bowel toxicity, provided evidence for the causal relation. Unfortunately, the case was not amenable to surgery and patient succumbed to the illness.<\/jats:p>","DOI":"10.1136\/bcr-2019-230727","type":"journal-article","created":{"date-parts":[[2019,11,11]],"date-time":"2019-11-11T06:15:45Z","timestamp":1573452945000},"page":"e230727","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Tumour-bowel fistula as a possible complication of pazopanib therapy in retroperitoneal leiomyosarcoma"],"prefix":"10.1136","volume":"12","author":[{"given":"Rodrigo Otavio Lami","family":"Pereira","sequence":"first","affiliation":[{"name":"Critical Care Medicine, Mayo Clinic, Jacksonville, Florida, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Payal R","family":"Patel","sequence":"additional","affiliation":[{"name":"Mayo Clinic Alix School of Medicine, Mayo Clinic, Rochester, Minnesota, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pramod K","family":"Guru","sequence":"additional","affiliation":[{"name":"Critical Care Medicine, Mayo Clinic, Jacksonville, Florida, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Devang K","family":"Sanghavi","sequence":"additional","affiliation":[{"name":"Critical Care Medicine, Mayo Clinic, Jacksonville, Florida, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,11,10]]},"reference":[{"key":"2025082804284856000_12.11.e230727.1","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1007\/s00261-013-9987-6","article-title":"Tumor-bowel fistula: what radiologists should know","volume":"38","author":"Tirumani","year":"2013","journal-title":"Abdom Imaging"},{"key":"2025082804284856000_12.11.e230727.2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-006-9337-9"},{"key":"2025082804284856000_12.11.e230727.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcsup.2013.07.016"},{"key":"2025082804284856000_12.11.e230727.4","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.12.8782"},{"key":"2025082804284856000_12.11.e230727.5","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-012-0238-8"},{"key":"2025082804284856000_12.11.e230727.6","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-010-9197-6"},{"key":"2025082804284856000_12.11.e230727.7","doi-asserted-by":"crossref","first-page":"28","DOI":"10.3348\/kjr.2017.18.1.28","article-title":"Molecular targeted therapy in modern oncology: imaging assessment of treatment response and toxicities","volume":"18","author":"Krajewski","year":"2017","journal-title":"Korean J Radiol"},{"key":"2025082804284856000_12.11.e230727.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2012.12.010"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2019-230727","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T11:28:57Z","timestamp":1756380537000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2019-230727"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11]]},"references-count":8,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2019,11,10]]},"published-print":{"date-parts":[[2019,11]]}},"alternative-id":["10.1136\/bcr-2019-230727"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2019-230727","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11]]}}}