{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T10:47:49Z","timestamp":1781002069510,"version":"3.54.1"},"reference-count":9,"publisher":"BMJ","issue":"10","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2019,9,26]]},"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:p>Platypnoea\u2013orthodeoxia syndrome (POS) is a rare disorder characterised by both dyspnoea (platypnoea) and arterial desaturation (orthodeoxia) in the upright position, with improvement in the supine position. We report an unusual case in which an 82-year-old woman developed severe hypoxaemia with POS after left total knee replacement. A significant difference in alveolar\u2013arterial blood gas oxygen tension was demonstrated, and hypoxaemia failed to respond to 100% oxygen supply. A patent foramen ovale with a right-to-left shunt was evident on transoesophageal echocardiogram employing colour Doppler and agitated normal saline studies. Interestingly, the patient\u2019s symptoms resolved within 6\u2009months with ongoing chest physiotherapy, without surgical or medical intervention.<\/jats:p>","DOI":"10.1136\/bcr-2019-230771","type":"journal-article","created":{"date-parts":[[2019,10,23]],"date-time":"2019-10-23T15:35:49Z","timestamp":1571844949000},"page":"e230771","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Platypnoea\u2013orthodeoxia after left total knee replacement"],"prefix":"10.1136","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8213-4621","authenticated-orcid":false,"given":"Taha","family":"Almufti","sequence":"first","affiliation":[{"name":"Medicine, Albury Wodonga Health, Wodonga, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franz","family":"Eversheim","sequence":"additional","affiliation":[{"name":"Medicine, Albury Wodonga Health, Wodonga, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brett","family":"Johnson","sequence":"additional","affiliation":[{"name":"Medicine, Albury Wodonga Health, Wodonga, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel Ayonmigbesimi","family":"Akra","sequence":"additional","affiliation":[{"name":"Emergency, Albury Wodonga Health Albury Campus, Albury, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2019,10,23]]},"reference":[{"key":"2025082709210842000_12.10.e230771.1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-726X(199905)47:1<64::AID-CCD15>3.0.CO;2-6"},{"key":"2025082709210842000_12.10.e230771.2","doi-asserted-by":"crossref","DOI":"10.1161\/circ.105.6.e47","article-title":"Mechanisms of platypnea-orthodeoxia: what causes water to flow uphill?","volume":"105","author":"Cheng","year":"2002","journal-title":"Circulation"},{"key":"2025082709210842000_12.10.e230771.3","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(12)60336-X"},{"key":"2025082709210842000_12.10.e230771.4","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2017-221714","article-title":"A case of platypnoea orthodeoxia following Laproscopic cholecystectomy","volume":"24","author":"Riddles","year":"2018","journal-title":"BMJ Case Rep"},{"key":"2025082709210842000_12.10.e230771.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2013.08.698"},{"key":"2025082709210842000_12.10.e230771.6","doi-asserted-by":"crossref","unstructured":"Vasant J , Jones S , Easaw J . 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