{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T13:21:59Z","timestamp":1779110519889,"version":"3.51.4"},"reference-count":7,"publisher":"BMJ","issue":"8","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2019,7,19]]},"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:p>Leukemoid reaction is a paraneoplastic phenomenon associated predominantly with solid tumours. Malignancies presenting with leukemoid reaction have a grave prognosis. It is defined as persistent neutrophil count greater than 50\u00d7103\u2009cells\/\u00b5L. We report a case of leukemoid reaction in a patient with metastatic penile cancer. A 60-year-old man with partial penectomy status for squamous cell carcinoma of penis on neoadjuvant chemotherapy, presented with left fungating inguinal lymphadenopathy and total leucocyte count 96\u00d7103\u2009cells\/\u00b5L and hypercalcaemia. Leucocytealkaline phosphatase (LAP) score was excessively elevated. The patient underwent left ilioinguinal block dissection along with vastus lateralis flap for defect reconstruction. Postoperatively, the neutrophil counts and serum calcium level normalised. The patient improved clinically and was discharged.<\/jats:p>","DOI":"10.1136\/bcr-2019-230826","type":"journal-article","created":{"date-parts":[[2019,8,13]],"date-time":"2019-08-13T07:05:13Z","timestamp":1565679913000},"page":"e230826","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Leukemoid reaction: a rare paraneoplastic event in a case of advanced penile cancer and its management"],"prefix":"10.1136","volume":"12","author":[{"given":"Amit Kumar","family":"Mishra","sequence":"first","affiliation":[{"name":"Department of Urology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ketan","family":"Mehra","sequence":"additional","affiliation":[{"name":"Department of Urology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramanitharan","family":"Manikandan","sequence":"additional","affiliation":[{"name":"Department of Urology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lalgudi Narayanan","family":"Dorairajan","sequence":"additional","affiliation":[{"name":"Department of Urology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,8,12]]},"reference":[{"key":"2025082802355990000_12.8.e230826.1","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-192610000-00005"},{"key":"2025082802355990000_12.8.e230826.2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24480"},{"key":"2025082802355990000_12.8.e230826.3","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-005-0330-y"},{"key":"2025082802355990000_12.8.e230826.4","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1080\/00365590310001638","article-title":"Granulocyte colony-stimulating factor may promote proliferation of human bladder cancer cells mediated by basic fibroblast growth factor","volume":"37","author":"Ohmi","year":"2003","journal-title":"Scand J Urol Nephrol"},{"key":"2025082802355990000_12.8.e230826.5","unstructured":"Curnutte JT , Coates TD . Disorders of phagocyte function and number. In: Hoffman R , Benz\u00a0EJ , Shattil SJ , eds. Hematology: basic principles and practice. 3rd edn. 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